Detailed information of TA system TA026331

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 2805681..2805890
• Replicon: chromosome
• Accession: NC_017173
• Organism: Clostridium difficile CF5

Toxin (Protein)

• Gene name: CD2517.1
• Uniprot ID: -
• Locus tag: CDCF5_RS12920
• Protein ID: WP_003431040.1
• Coordinates: 2805732..2805890 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	RCd8
Locus tag	-
Coordinates	2805681..2805815 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDCF5_RS12890	2800884..2801084	+	201	WP_003431034.1	cold-shock protein	-
CDCF5_RS12895	2801515..2802852	+	1338	WP_003431035.1	ATP-binding protein	-
CDCF5_RS12900	2802895..2803476	+	582	WP_003431036.1	accessory gene regulator B family protein	-
CDCF5_RS12905	2803494..2803655	+	162	WP_003431037.1	cyclic lactone autoinducer peptide	-
CDCF5_RS12910	2803677..2804474	-	798	WP_003431038.1	N-acetylmuramoyl-L-alanine amidase	-
CDCF5_RS12915	2804471..2804731	-	261	WP_003431039.1	phage holin family protein	-
-	2805681..2805815	+	135	NuclAT_2	-	Antitoxin
CDCF5_RS12920	2805732..2805890	-	159	WP_003431040.1	hypothetical protein	Toxin
CDCF5_RS12925	2806248..2807618	-	1371	WP_003431041.1	cell wall-binding protein Cwp29	-
CDCF5_RS12930	2807900..2807998	+	99	Protein_2512	Arm DNA-binding domain-containing protein	-
CDCF5_RS12935	2808017..2808439	+	423	Protein_2513	hypothetical protein	-
CDCF5_RS12940	2808757..2808942	+	186	WP_107615967.1	tyrosine-type recombinase/integrase	-
CDCF5_RS12945	2809305..2809385	-	81	Protein_2515	VOC family protein	-
CDCF5_RS12950	2809425..2810093	-	669	WP_003431044.1	VanZ family protein	-
CDCF5_RS12955	2810192..2810575	-	384	WP_071599195.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2799719..2814788	15069

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 5982.18 Da
• Isoelectric Point: 11.3102

>T26331 WP_003431040.1 NC_017173:c2805890-2805732 [Clostridioides difficile CF5]
MDNFLQGILASLSASLIVYVASKLFRKRKKPLKAATKSGWEFDLKIRFHKTK

Nucleotide

• Length: 159 bp

>T26331 NC_017173:c2805890-2805732 [Clostridioides difficile CF5]
ATGGATAATTTTTTACAAGGCATACTAGCAAGTCTATCTGCTAGCTTAATAGTTTATGTAGCTAGCAAACTATTTAGAAA
GCGTAAAAAACCACTCAAAGCGGCAACTAAGAGTGGTTGGGAATTTGATTTAAAAATCAGATTCCATAAAACTAAGTAA

Antitoxin

Nucleotide

• Length: 135 bp

>AT26331 NC_017173:2805681-2805815 [Clostridioides difficile CF5]
AAGAAGAGCTACAATCTATTTTGCTGTAGAGTGGAGTTCATAATTTAGAAATTACTTAGTTTTATGGAATCTGATTTTTA
AATCAAATTCCCAACCACTCTTAGTTGCCGCTTTGAGTGGTTTTTTACGCTTTCT

Structures

Antitoxin