Detailed information of TA system TA026327

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1740767..1740981
• Replicon: chromosome
• Accession: NC_017173
• Organism: Clostridium difficile CF5

Toxin (Protein)

• Gene name: CD0956.2
• Uniprot ID: Q183Z5
• Locus tag: CDCF5_RS08090
• Protein ID: WP_003429855.1
• Coordinates: 1740767..1740928 (+)
• Length: 54 a.a.

Antitoxin (RNA)

Gene name	RCd10
Locus tag	-
Coordinates	1740848..1740981 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDCF5_RS08045	1736106..1736339	+	234	WP_003429842.1	hypothetical protein	-
CDCF5_RS08050	1736349..1736750	+	402	WP_021379034.1	hypothetical protein	-
CDCF5_RS08055	1736744..1737091	+	348	WP_003429844.1	hypothetical protein	-
CDCF5_RS08060	1737091..1737516	+	426	WP_003429845.1	HK97 gp10 family phage protein	-
CDCF5_RS08065	1737509..1737946	+	438	WP_003429846.1	hypothetical protein	-
CDCF5_RS08070	1737939..1738115	+	177	WP_021358991.1	hypothetical protein	-
CDCF5_RS08075	1738117..1739427	+	1311	WP_003429848.1	phage tail sheath family protein	-
CDCF5_RS08080	1739444..1739914	+	471	WP_003429851.1	phage tail tube protein	-
CDCF5_RS08085	1739986..1740426	+	441	WP_003429853.1	phage portal protein	-
CDCF5_RS08090	1740767..1740928	+	162	WP_003429855.1	hypothetical protein	Toxin
-	1740848..1740981	-	134	NuclAT_0	-	Antitoxin
-	1740848..1740981	-	134	NuclAT_1	-	Antitoxin
-	1741326..1741374	-	49	NuclAT_5	-	-
-	1741326..1741374	-	49	NuclAT_7	-	-
-	1742438..1742543	-	106	NuclAT_4	-	-
-	1742438..1742543	-	106	NuclAT_6	-	-
CDCF5_RS08095	1743891..1744079	+	189	WP_003429858.1	hypothetical protein	-
CDCF5_RS08100	1744198..1745064	+	867	Protein_1546	phage repressor protein	-
CDCF5_RS08105	1745127..1745303	+	177	WP_003429861.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1707845..1779158	71313

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 6120.42 Da
• Isoelectric Point: 10.8938

>T26327 WP_003429855.1 NC_017173:1740767-1740928 [Clostridioides difficile CF5]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Nucleotide

• Length: 162 bp

>T26327 NC_017173:1740767-1740928 [Clostridioides difficile CF5]
ATGAATAACTTTTTACTTAATGTAATAGCTGGCGTTATTGCTAGTTTAATATTTTGCTTAATTTGTAAAGTATTTCTAAA
AGTAAAAAGCCACTCAACTCGTGGCAAGAGTAAAAGTGGCTGGGAATTTGATTTTAAAATCAAGTTCCATAAGTTCAAAT
AG

Antitoxin

Nucleotide

• Length: 134 bp

>AT26327 NC_017173:c1740981-1740848 [Clostridioides difficile CF5]
AAGAAGAACTACAATCTATTTTGCGGTAGAGTGAAGTTCATAATTAAATGAATCTATTTGAACTTATGGAACTTGATTTT
AAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Structures

Toxin

• AlphaFold DB: A0A069AVN2

Antitoxin