Detailed information of TA system TA026325

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1326557..1326762
• Replicon: chromosome
• Accession: NC_017173
• Organism: Clostridium difficile CF5

Toxin (Protein)

• Gene name: CD1233.1
• Uniprot ID: A0A069A9H6
• Locus tag: CDCF5_RS18895
• Protein ID: WP_009896140.1
• Coordinates: 1326557..1326709 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	SQ808
Locus tag	-
Coordinates	1326689..1326762 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CDCF5_RS06115	1322026..1322310	-	285	WP_003419254.1	sigma-70 family RNA polymerase sigma factor	-
CDCF5_RS06120	1322333..1323850	-	1518	WP_003433404.1	recombinase family protein	-
CDCF5_RS06125	1323975..1324796	-	822	WP_003433401.1	tetratricopeptide repeat protein	-
CDCF5_RS06130	1324987..1326414	+	1428	WP_021387779.1	cell wall-binding protein Cwp26	-
CDCF5_RS18895	1326557..1326709	+	153	WP_009896140.1	hypothetical protein	Toxin
-	1326689..1326762	-	74	NuclAT_8	-	Antitoxin
CDCF5_RS06135	1327743..1327967	-	225	WP_003433396.1	helix-turn-helix domain-containing protein	-
CDCF5_RS06140	1328657..1328812	+	156	WP_003433394.1	hypothetical protein	-
CDCF5_RS06145	1329058..1329309	+	252	WP_003419270.1	hypothetical protein	-
CDCF5_RS06150	1330529..1330912	-	384	WP_003433385.1	hypothetical protein	-
CDCF5_RS06155	1331039..1331383	+	345	WP_003433383.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5811.96 Da
• Isoelectric Point: 11.1039

>T26325 WP_009896140.1 NC_017173:1326557-1326709 [Clostridioides difficile CF5]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Nucleotide

• Length: 153 bp

>T26325 NC_017173:1326557-1326709 [Clostridioides difficile CF5]
ATGGATAACTTTTTGTTTAATGTTTTAGCTAGTTTAACAGCTAGTGTGGTAGTTTACTTAATCAGTAAACTATTCAAAAA
AGCAAAAAGCCACTCTCGCACAAAGAGTGACTTACGAGTTGAATTTAAATTTATATTTAAATCCAAAAAATAA

Antitoxin

Nucleotide

• Length: 74 bp

>AT26325 NC_017173:c1326762-1326689 [Clostridioides difficile CF5]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Structures

Toxin

• AlphaFold DB: A0A069A9H6

Antitoxin