Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 2179893..2180089 Replicon chromosome
Accession NZ_CP107552
Organism Clostridioides difficile strain S0756_078

Toxin (Protein)


Gene name CD1418.2 Uniprot ID D5Q3X5
Locus tag J5O10_RS10360 Protein ID WP_003424190.1
Coordinates 2179937..2180089 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name CD630_n00500
Locus tag -
Coordinates 2179893..2179993 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5O10_RS10340 (2175160) 2175160..2175417 - 258 WP_003424182.1 hypothetical protein -
J5O10_RS10345 (2175404) 2175404..2175637 - 234 WP_003424184.1 hypothetical protein -
J5O10_RS10350 (2175825) 2175825..2176013 + 189 WP_003424185.1 helix-turn-helix transcriptional regulator -
J5O10_RS10355 (2176216) 2176216..2176347 - 132 WP_003424186.1 hypothetical protein -
- (2179893) 2179893..2179993 + 101 NuclAT_0 - Antitoxin
- (2179893) 2179893..2179993 + 101 NuclAT_0 - Antitoxin
J5O10_RS10360 (2179937) 2179937..2180089 - 153 WP_003424190.1 hypothetical protein Toxin
J5O10_RS10365 (2180609) 2180609..2180851 + 243 WP_003424191.1 hypothetical protein -
J5O10_RS10370 (2180932) 2180932..2181462 + 531 WP_003424192.1 site-specific integrase -
J5O10_RS10375 (2182007) 2182007..2182852 + 846 WP_003424194.1 DUF4878 domain-containing protein -
J5O10_RS10380 (2183076) 2183076..2183240 - 165 WP_003424195.1 hypothetical protein -
J5O10_RS10385 (2183772) 2183772..2183963 - 192 WP_003424196.1 carboxymuconolactone decarboxylase family protein -
J5O10_RS10390 (2183963) 2183963..2184103 - 141 WP_003424197.1 hypothetical protein -
J5O10_RS10395 (2184363) 2184363..2185004 - 642 WP_003424198.1 SdpI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5744.78 Da        Isoelectric Point: 10.6276

>T261731 WP_003424190.1 NZ_CP107552:c2180089-2179937 [Clostridioides difficile]
MDNFLQGILASLVASLIVYLTSKLFKKVKSHSGRSDFSFELEIKFKKNKH

Download         Length: 153 bp

Antitoxin


Download         Length: 101 bp

>AT261731 NZ_CP107552:2179893-2179993 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A449XCJ1

Antitoxin

Download structure file

References