Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1718447..1718667 Replicon chromosome
Accession NZ_CP107113
Organism Clostridioides difficile strain R_cdtRKO10.3

Toxin (Protein)


Gene name CD0956.2 Uniprot ID Q183Z5
Locus tag OGM24_RS08080 Protein ID WP_003429855.1
Coordinates 1718447..1718608 (+) Length 54 a.a.

Antitoxin (RNA)


Gene name RCd10
Locus tag -
Coordinates 1718528..1718667 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGM24_RS08050 (OGM24_08050) 1714304..1714741 + 438 WP_009888839.1 hypothetical protein -
OGM24_RS08055 (OGM24_08055) 1714734..1714910 + 177 WP_009888840.1 hypothetical protein -
OGM24_RS08060 (OGM24_08060) 1714911..1716221 + 1311 WP_009893136.1 phage tail sheath family protein -
OGM24_RS08065 (OGM24_08065) 1716238..1716708 + 471 WP_009888842.1 phage tail tube protein -
OGM24_RS08070 (OGM24_08070) 1716767..1717594 + 828 WP_009888843.1 hypothetical protein -
OGM24_RS08075 (OGM24_08075) 1717666..1718106 + 441 WP_003429853.1 phage portal protein -
OGM24_RS08080 (OGM24_08080) 1718447..1718608 + 162 WP_003429855.1 hypothetical protein Toxin
- 1718528..1718667 - 140 - - Antitoxin
OGM24_RS08085 (OGM24_08085) 1719945..1720133 + 189 WP_003429858.1 hypothetical protein -
OGM24_RS08090 (OGM24_08090) 1720252..1721118 + 867 WP_009888845.1 BRO family protein -
OGM24_RS08095 (OGM24_08095) 1721171..1721305 + 135 WP_009888846.1 hypothetical protein -
OGM24_RS08100 (OGM24_08100) 1721983..1722510 + 528 WP_009888847.1 DUF4352 domain-containing protein -
OGM24_RS08105 (OGM24_08105) 1722648..1723415 + 768 WP_009888848.1 DUF4428 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1684658..1751795 67137


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 6120.42 Da        Isoelectric Point: 10.8938

>T260542 WP_003429855.1 NZ_CP107113:1718447-1718608 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Download         Length: 162 bp

Antitoxin


Download         Length: 140 bp

>AT260542 NZ_CP107113:c1718667-1718528 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGACAGTAGAGTGAAGTTCATAATTTAAACAATTAGTAATTATTTAAATTTGTGGAACTT
GATTTTAAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069AVN2

Antitoxin

Download structure file

References