Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) CD-RCd/-
Location 1746550..1746770 Replicon chromosome
Accession NZ_CP107108
Organism Clostridioides difficile strain R_phiCD75-3

Toxin (Protein)


Gene name CD0956.2 Uniprot ID Q183Z5
Locus tag OGM26_RS08320 Protein ID WP_003429855.1
Coordinates 1746550..1746711 (+) Length 54 a.a.

Antitoxin (RNA)


Gene name RCd10
Locus tag -
Coordinates 1746631..1746770 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGM26_RS08290 (OGM26_08290) 1742407..1742844 + 438 WP_009888839.1 hypothetical protein -
OGM26_RS08295 (OGM26_08295) 1742837..1743013 + 177 WP_009888840.1 hypothetical protein -
OGM26_RS08300 (OGM26_08300) 1743014..1744324 + 1311 WP_009893136.1 phage tail sheath family protein -
OGM26_RS08305 (OGM26_08305) 1744341..1744811 + 471 WP_009888842.1 phage tail tube protein -
OGM26_RS08310 (OGM26_08310) 1744870..1745697 + 828 WP_009888843.1 hypothetical protein -
OGM26_RS08315 (OGM26_08315) 1745769..1746209 + 441 WP_003429853.1 phage portal protein -
OGM26_RS08320 (OGM26_08320) 1746550..1746711 + 162 WP_003429855.1 hypothetical protein Toxin
- 1746631..1746770 - 140 - - Antitoxin
OGM26_RS08325 (OGM26_08325) 1748048..1748236 + 189 WP_003429858.1 hypothetical protein -
OGM26_RS08330 (OGM26_08330) 1748355..1749221 + 867 WP_009888845.1 BRO family protein -
OGM26_RS08335 (OGM26_08335) 1749274..1749408 + 135 WP_009888846.1 hypothetical protein -
OGM26_RS08340 (OGM26_08340) 1750086..1750613 + 528 WP_009888847.1 DUF4352 domain-containing protein -
OGM26_RS08345 (OGM26_08345) 1750751..1751518 + 768 WP_009888848.1 DUF4428 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1712761..1779199 66438


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 6120.42 Da        Isoelectric Point: 10.8938

>T260522 WP_003429855.1 NZ_CP107108:1746550-1746711 [Clostridioides difficile]
MNNFLLNVIAGVIASLIFCLICKVFLKVKSHSTRGKSKSGWEFDFKIKFHKFK

Download         Length: 162 bp

Antitoxin


Download         Length: 140 bp

>AT260522 NZ_CP107108:c1746770-1746631 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTGACAGTAGAGTGAAGTTCATAATTTAAACAATTAGTAATTATTTAAATTTGTGGAACTT
GATTTTAAAATCAAATTCCCAGCCACTTTTACTCTTGCCACGAGTTGAGTGGCTTTTTAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069AVN2

Antitoxin

Download structure file

References