Detailed information of TA system TA259373

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 2850348..2850762
• Replicon: chromosome
• Accession: NZ_CP104858
• Organism: Salmonella sp. 3C

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: M7RBD3
• Locus tag: N7E69_RS13420
• Protein ID: WP_000994230.1
• Coordinates: 2850348..2850605 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	2850430..2850762 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N7E69_RS13390	2845621..2845904	+	284	Protein_2597	RHS repeat-associated core domain-containing protein	-
N7E69_RS13395	2845962..2846282	+	321	WP_016695071.1	HNH endonuclease	-
N7E69_RS13400	2846304..2846642	+	339	WP_000201550.1	hypothetical protein	-
N7E69_RS13405	2846760..2846969	-	210	WP_001675680.1	SymE family type I addiction module toxin	-
N7E69_RS13410	2847017..2849839	+	2823	Protein_2601	RHS domain-containing protein	-
N7E69_RS13415	2849836..2850282	+	447	WP_000171102.1	hypothetical protein	-
N7E69_RS13420	2850348..2850605	-	258	WP_000994230.1	SymE family type I addiction module toxin	Toxin
-	2850430..2850762	+	333	-	-	Antitoxin
N7E69_RS13425	2850940..2851173	+	234	WP_124084119.1	hypothetical protein	-
N7E69_RS13430	2851731..2852048	+	318	WP_001751277.1	hypothetical protein	-
N7E69_RS13435	2852045..2852512	+	468	WP_000828183.1	sugar tyrosine-protein kinase	-
N7E69_RS13440	2852828..2853106	+	279	WP_012543321.1	hypothetical protein	-
N7E69_RS13445	2853173..2853487	-	315	WP_072100769.1	SymE family type I addiction module toxin	-
N7E69_RS13450	2853540..2853749	+	210	WP_001676010.1	hypothetical protein	-
N7E69_RS13455	2853670..2854240	+	571	Protein_2610	integrase core domain-containing protein	-
N7E69_RS13460	2855049..2855501	+	453	WP_001675682.1	Saf-pilin pilus formation protein SafA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2845909..2864134	18225
	-	flank	IS/Tn	-	-	2853962..2854240	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9490.94 Da
• Isoelectric Point: 9.5519

>T259373 WP_000994230.1 NZ_CP104858:c2850605-2850348 [Salmonella sp. 3C]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYQAKQVVKGI
KDVLV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 333 bp

>AT259373 NZ_CP104858:2850430-2850762 [Salmonella sp. 3C]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A656IER2

Antitoxin