259102

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 19496..20027 Replicon plasmid unnamed2
Accession NZ_CP104747
Organism Erwinia pyrifoliae strain CP20113301

Toxin (Protein)


Gene name stbE Uniprot ID E3DL65
Locus tag NYP80_RS19545 Protein ID WP_011078058.1
Coordinates 19496..19783 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID Q7X3U3
Locus tag NYP80_RS19550 Protein ID WP_011078059.1
Coordinates 19773..20027 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP80_RS19525 (NYP80_19525) 15996..17552 - 1557 WP_041473953.1 methyl-accepting chemotaxis protein -
NYP80_RS19530 (NYP80_19530) 18060..18473 - 414 WP_011113999.1 helix-turn-helix domain-containing protein -
NYP80_RS19535 (NYP80_19535) 18474..18788 - 315 WP_261648176.1 type II toxin-antitoxin system HigB family toxin -
NYP80_RS19540 (NYP80_19540) 19052..19336 - 285 WP_011078079.1 VF530 family DNA-binding protein -
NYP80_RS19545 (NYP80_19545) 19496..19783 - 288 WP_011078058.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYP80_RS19550 (NYP80_19550) 19773..20027 - 255 WP_011078059.1 plasmid stabilization protein Antitoxin
NYP80_RS19555 (NYP80_19555) 20238..21203 - 966 WP_011078060.1 ThiF family adenylyltransferase -
NYP80_RS19560 (NYP80_19560) 21219..21977 - 759 WP_012814638.1 thiazole synthase -
NYP80_RS19565 (NYP80_19565) 21981..22178 - 198 WP_012814637.1 sulfur carrier protein ThiS -
NYP80_RS19570 (NYP80_19570) 22175..23107 - 933 WP_041473952.1 FAD-dependent oxidoreductase -
NYP80_RS19575 (NYP80_19575) 23483..23644 - 162 Protein_27 Txe/YoeB family addiction module toxin -
NYP80_RS19580 (NYP80_19580) 23824..24408 + 585 WP_012814636.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid - pla 1..34637 34637
flank IS/Tn - - 23824..24408 584


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11197.09 Da        Isoelectric Point: 10.6516

>T259102 WP_011078058.1 NZ_CP104747:c19783-19496 [Erwinia pyrifoliae]
MTYKLKFVPSAEKEWKRLGHPVREQFKKKLAERLENPRVPSAQLHGRKDQYKIKLKSAGYRLVYLVQEHTITIMVMGIGK
REGNQIYSDTENRLP

Download         Length: 288 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9210.56 Da        Isoelectric Point: 3.8705

>AT259102 WP_011078059.1 NZ_CP104747:c20027-19773 [Erwinia pyrifoliae]
MAFNILTNTAASITDLKRDPMGTVRAAEGETIAILNRNEPAFYCVPPAMYAYLMELAEDAELGCIVDDRMSELPVAKEIS
LDDL

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3DL65

Antitoxin

Source ID Structure
AlphaFold DB Q7X3U3

References