Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1347727..1348526 Replicon chromosome
Accession NZ_CP104639
Organism Escherichia coli strain PNUSAE014970

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag N4555_RS06630 Protein ID WP_000347273.1
Coordinates 1348062..1348526 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID C3ST72
Locus tag N4555_RS06625 Protein ID WP_001302819.1
Coordinates 1347727..1348062 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4555_RS06610 (1343512) 1343512..1344282 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
N4555_RS06615 (1344298) 1344298..1345632 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
N4555_RS06620 (1346007) 1346007..1347578 + 1572 WP_001273776.1 galactarate dehydratase -
N4555_RS06625 (1347727) 1347727..1348062 + 336 WP_001302819.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
N4555_RS06630 (1348062) 1348062..1348526 + 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
N4555_RS06635 (1348581) 1348581..1349390 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
N4555_RS06640 (1349639) 1349639..1350919 + 1281 WP_000681927.1 tagatose-bisphosphate aldolase subunit KbaZ -
N4555_RS06645 (1350942) 1350942..1351415 + 474 WP_001301475.1 PTS N-acetylgalactosamine transporter subunit IIB -
N4555_RS06650 (1351426) 1351426..1352205 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
N4555_RS06655 (1352195) 1352195..1353073 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
N4555_RS06660 (1353091) 1353091..1353525 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1338373..1348526 10153


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T258713 WP_000347273.1 NZ_CP104639:1348062-1348526 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12388.97 Da        Isoelectric Point: 4.8616

>AT258713 WP_001302819.1 NZ_CP104639:1347727-1348062 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDTDIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure

References