Detailed information of TA system TA258068

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3643960..3644374
• Replicon: chromosome
• Accession: NZ_CP104482
• Organism: Salmonella enterica strain SalSpp_sample_08_No.4

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V5ZAW1
• Locus tag: N4230_RS17970
• Protein ID: WP_001749073.1
• Coordinates: 3644117..3644374 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3643960..3644292 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N4230_RS17945	3640186..3640923	-	738	WP_001537407.1	pili assembly chaperone SafB	-
N4230_RS17950	3641007..3641501	-	495	WP_093984220.1	pilus assembly protein	-
N4230_RS17955	3642265..3642965	-	701	Protein_3510	integrase core domain-containing protein	-
N4230_RS17960	3643018..3643332	+	315	WP_011233128.1	SymE family type I addiction module toxin	-
N4230_RS17965	3643399..3643677	-	279	WP_077905025.1	hypothetical protein	-
-	3643960..3644292	-	333	-	-	Antitoxin
N4230_RS17970	3644117..3644374	+	258	WP_001749073.1	SymE family type I addiction module toxin	Toxin
N4230_RS17975	3644465..3644842	-	378	WP_000739708.1	Imm8 family immunity protein	-
N4230_RS17980	3645575..3645940	-	366	WP_001231281.1	hypothetical protein	-
N4230_RS17985	3645906..3646853	-	948	Protein_3516	RHS domain-containing protein	-
N4230_RS17990	3647279..3647413	+	135	Protein_3517	type I toxin-antitoxin system SymE family toxin	-
N4230_RS17995	3647482..3647769	-	288	WP_017442165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3633110..3669972	36862
	-	flank	IS/Tn	-	-	3642285..3642542	257

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9561.85 Da
• Isoelectric Point: 5.0770

>T258068 WP_001749073.1 NZ_CP104482:3644117-3644374 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGRSITVKISQECIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 333 bp

>AT258068 NZ_CP104482:c3644292-3643960 [Salmonella enterica]
TCCGCCATCAGCACAATACACTCCTGTGAAATCTTCACGGTGATGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCAGCCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V5ZAW1

Antitoxin