Detailed information of TA system TA258051

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3763384..3763816
• Replicon: chromosome
• Accession: NZ_CP104479
• Organism: Salmonella enterica strain SalSpp_sample_09_No.5

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A742L7W2
• Locus tag: N4G50_RS18660
• Protein ID: WP_024156826.1
• Coordinates: 3763541..3763816 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3763384..3763806 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N4G50_RS18620	3759671..3759829	-	159	WP_000564358.1	hypothetical protein	-
N4G50_RS18625	3759821..3760378	+	558	Protein_3646	ATP-binding protein	-
N4G50_RS18630	3760418..3760604	-	187	Protein_3647	transposase	-
N4G50_RS18635	3760657..3760971	+	315	WP_077908685.1	SymE family type I addiction module toxin	-
N4G50_RS18640	3761038..3761316	-	279	WP_077908688.1	hypothetical protein	-
N4G50_RS18645	3761633..3762100	-	468	WP_024156825.1	hypothetical protein	-
N4G50_RS18650	3762097..3762417	-	321	WP_223202033.1	hypothetical protein	-
N4G50_RS18655	3762974..3763207	-	234	WP_124084119.1	hypothetical protein	-
-	3763384..3763806	-	423	-	-	Antitoxin
N4G50_RS18660	3763541..3763816	+	276	WP_024156826.1	SymE family type I addiction module toxin	Toxin
N4G50_RS18665	3763870..3764181	-	312	WP_000849719.1	hypothetical protein	-
N4G50_RS18670	3764194..3764637	-	444	WP_217903324.1	HNH endonuclease	-
N4G50_RS18675	3764819..3765208	-	390	WP_000264306.1	Imm50 family immunity protein	-
N4G50_RS18680	3765223..3765805	-	583	Protein_3657	HNH/endonuclease VII fold putative polymorphic toxin	-
N4G50_RS18685	3765942..3766208	-	267	WP_029412312.1	MafI family immunity protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3750537..3766208	15671

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10110.52 Da
• Isoelectric Point: 6.7017

>T258051 WP_024156826.1 NZ_CP104479:3763541-3763816 [Salmonella enterica]
MNASGVSVRHINSETCITTCYSQIPSLHLKGDWQEEAGFETGRSVTVKISEGCLILMAETDEVRELRKELYQVKKSMKHI
KAGVNDVVNGN

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 423 bp

>AT258051 NZ_CP104479:c3763806-3763384 [Salmonella enterica]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGCTCCCTCAC
TTCGTCCGTCTCAGCCATCAGGATCAAACATCCCTCGGAGATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCAGGCTGGGGATTTGTGAGTAACAGGTGGTTATACAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATACTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACTGTGCCCCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCA
ACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A742L7W2

Antitoxin