Detailed information of TA system TA257094

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 734625..735039
• Replicon: chromosome
• Accession: NZ_CP104049
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain Sal-FJ2064

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V3U6I8
• Locus tag: NXZ70_RS03420
• Protein ID: WP_023203422.1
• Coordinates: 734625..734882 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	734707..735039 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NXZ70_RS03405	732950..733471	+	522	WP_023203424.1	SMI1/KNR4 family protein	-
NXZ70_RS03410	733862..734239	+	378	WP_233152415.1	DUF4329 domain-containing protein	-
NXZ70_RS03415	734258..734566	+	309	WP_023203423.1	hypothetical protein	-
NXZ70_RS03420	734625..734882	-	258	WP_023203422.1	SymE family type I addiction module toxin	Toxin
-	734707..735039	+	333	-	-	Antitoxin
NXZ70_RS03425	735955..736230	+	276	WP_223163371.1	hypothetical protein	-
NXZ70_RS03430	736406..737575	+	1170	WP_001749026.1	tyrosine-type recombinase/integrase	-
NXZ70_RS03435	737638..739494	-	1857	WP_250297417.1	phage head-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	715656..781224	65568

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.71 Da
• Isoelectric Point: 7.2431

>T257094 WP_023203422.1 NZ_CP104049:c734882-734625 [Salmonella enterica subsp. enterica serovar Kentucky]
MNASGASVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 333 bp

>AT257094 NZ_CP104049:734707-735039 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V3U6I8

Antitoxin