Detailed information of TA system TA256670

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 1245624..1246038
• Replicon: chromosome
• Accession: NZ_CP103791
• Organism: Salmonella enterica subsp. enterica serovar Infantis strain MRS17_00712

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5I5SV33
• Locus tag: NYQ90_RS05970
• Protein ID: WP_023243487.1
• Coordinates: 1245624..1245881 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	1245706..1246038 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NYQ90_RS05965	1245213..1245557	+	345	WP_023218822.1	hypothetical protein	-
NYQ90_RS05970	1245624..1245881	-	258	WP_023243487.1	SymE family type I addiction module toxin	Toxin
-	1245706..1246038	+	333	-	-	Antitoxin
NYQ90_RS05975	1246215..1246508	+	294	WP_039515457.1	hypothetical protein	-
NYQ90_RS05980	1247325..1247792	+	468	WP_000828178.1	sugar tyrosine-protein kinase	-
NYQ90_RS05985	1248109..1248387	+	279	WP_077677834.1	hypothetical protein	-
NYQ90_RS05990	1248454..1248768	-	315	WP_023892102.1	SymE family type I addiction module toxin	-
NYQ90_RS05995	1248821..1249522	+	702	Protein_1165	integrase core domain-containing protein	-
NYQ90_RS06000	1250221..1250784	+	564	WP_023993992.1	Saf-pilin pilus formation protein SafA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1223000..1266860	43860
	-	flank	IS/Tn	-	-	1249244..1249522	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9498.73 Da
• Isoelectric Point: 6.2112

>T256670 WP_023243487.1 NZ_CP103791:c1245881-1245624 [Salmonella enterica subsp. enterica serovar Infantis]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFETGRSVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 333 bp

>AT256670 NZ_CP103791:1245706-1246038 [Salmonella enterica subsp. enterica serovar Infantis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCTCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5I5SV33

Antitoxin