Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 18067..18795 | Replicon | plasmid unnamed |
| Accession | NZ_CP103446 | ||
| Organism | Erwinia pyrifoliae strain CP201486 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | NYP84_RS19375 | Protein ID | WP_041473956.1 |
| Coordinates | 18481..18795 (-) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | NYP84_RS19370 | Protein ID | WP_011113999.1 |
| Coordinates | 18067..18480 (-) | Length | 138 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NYP84_RS19355 (NYP84_19355) | 13317..14174 | - | 858 | WP_012814642.1 | LysR family transcriptional regulator | - |
| NYP84_RS19360 (NYP84_19360) | 14315..15703 | + | 1389 | WP_041473957.1 | NAD-dependent succinate-semialdehyde dehydrogenase | - |
| NYP84_RS19365 (NYP84_19365) | 16003..17559 | - | 1557 | WP_041473953.1 | methyl-accepting chemotaxis protein | - |
| NYP84_RS19370 (NYP84_19370) | 18067..18480 | - | 414 | WP_011113999.1 | helix-turn-helix domain-containing protein | Antitoxin |
| NYP84_RS19375 (NYP84_19375) | 18481..18795 | - | 315 | WP_041473956.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| NYP84_RS19380 (NYP84_19380) | 19059..19343 | - | 285 | WP_011078079.1 | VF530 family DNA-binding protein | - |
| NYP84_RS19385 (NYP84_19385) | 19503..19790 | - | 288 | WP_011078058.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| NYP84_RS19390 (NYP84_19390) | 19780..20034 | - | 255 | WP_011078059.1 | plasmid stabilization protein | - |
| NYP84_RS19395 (NYP84_19395) | 20245..21210 | - | 966 | WP_011078060.1 | ThiF family adenylyltransferase | - |
| NYP84_RS19400 (NYP84_19400) | 21226..21984 | - | 759 | WP_012814638.1 | thiazole synthase | - |
| NYP84_RS19405 (NYP84_19405) | 21988..22185 | - | 198 | WP_012814637.1 | sulfur carrier protein ThiS | - |
| NYP84_RS19410 (NYP84_19410) | 22182..23114 | - | 933 | WP_041473952.1 | FAD-dependent oxidoreductase | - |
| NYP84_RS19415 (NYP84_19415) | 23490..23651 | - | 162 | Protein_26 | Txe/YoeB family addiction module toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Non-Mobilizable plasmid | - | pla | 1..34668 | 34668 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 12227.32 Da Isoelectric Point: 10.2275
>T255055 WP_041473956.1 NZ_CP103446:c18795-18481 [Erwinia pyrifoliae]
MHLISRSMIKDATDKYPQHSRELLALMIAIEKGYFKAPEALKAAFPSLDNLKYLDKHYVINIGRNDLRLVALVFFESQKF
YVRHVFTHKEYDVFTALHRTKGKK
MHLISRSMIKDATDKYPQHSRELLALMIAIEKGYFKAPEALKAAFPSLDNLKYLDKHYVINIGRNDLRLVALVFFESQKF
YVRHVFTHKEYDVFTALHRTKGKK
Download Length: 315 bp
Antitoxin
Download Length: 138 a.a. Molecular weight: 14905.32 Da Isoelectric Point: 4.6233
>AT255055 WP_011113999.1 NZ_CP103446:c18480-18067 [Erwinia pyrifoliae]
MLVADIIKAGEALTAVAPFLAGITDKRQHAEALEFVEHLLLNDPENPLLDLVCAKITAYEDTAPEFAEFNAQLAAMPAGV
AMIRLLLDQHDLTLSDLPEIGSKSMVSRVLNGERKLTLEHAKKLATRFAISPALFID
MLVADIIKAGEALTAVAPFLAGITDKRQHAEALEFVEHLLLNDPENPLLDLVCAKITAYEDTAPEFAEFNAQLAAMPAGV
AMIRLLLDQHDLTLSDLPEIGSKSMVSRVLNGERKLTLEHAKKLATRFAISPALFID
Download Length: 414 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|