Detailed information of TA system TA254204

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 1116743..1116994
• Replicon: chromosome
• Accession: NZ_CP102827
• Organism: Salmonella enterica subsp. enterica serovar Indiana strain XZ14C1328

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: NV345_RS05135
• Protein ID: WP_131166435.1
• Coordinates: 1116743..1116994 (-)
• Length: 84 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	1116753..1116978 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NV345_RS05115	1114099..1114707	+	609	WP_053505599.1	hypothetical protein	-
NV345_RS05120	1114850..1114987	-	138	WP_023227287.1	hypothetical protein	-
NV345_RS05125	1115007..1115852	+	846	Protein_981	RHS domain-containing protein	-
NV345_RS05130	1116233..1116697	+	465	WP_127201574.1	hypothetical protein	-
NV345_RS05135	1116743..1116994	-	252	WP_131166435.1	SymE family type I addiction module toxin	Toxin
-	1116753..1116978	+	226	-	-	Antitoxin
NV345_RS05140	1117058..1117759	+	702	Protein_984	integrase core domain-containing protein	-
NV345_RS05145	1118527..1119021	+	495	WP_051129373.1	hypothetical protein	-
NV345_RS05150	1119154..1119651	+	498	WP_051129374.1	Saf-pilin pilus formation protein SafA	-
NV345_RS05155	1119726..1120466	+	741	WP_051129375.1	pili assembly chaperone SafB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1094039..1137600	43561
	-	flank	IS/Tn	-	-	1117481..1117759	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (10-48)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9451.82 Da
• Isoelectric Point: 8.0365

>T254204 WP_131166435.1 NZ_CP102827:c1116994-1116743 [Salmonella enterica subsp. enterica serovar Indiana]
MRDTYKTHMTTYYSRIPSLHLKGDWLAEAGFDTGASVTVKISEGCLTLIVETDEVRDLRRELYQVKKSMKHIKAGVYDVV
NGN

Nucleotide

• Length: 252 bp

Antitoxin

Nucleotide

• Length: 226 bp

>AT254204 NZ_CP102827:1116753-1116978 [Salmonella enterica subsp. enterica serovar Indiana]
TTCACCACATCATATACCCCCGCCTTAATGTGCTTCATCGACTTTTTCACCTGATAAAGCTCCCTCCGTAGATCCCTCAC
TTCGTCTGTCTCCACAATCAGAGTCAAACACCCTTCGGAGATCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCAGGCTGGGGATGCGCGAGTAATAGGTGGTCATGTGGGTTT

Structures

Antitoxin