Detailed information of TA system TA254145

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 1280635..1281049
• Replicon: chromosome
• Accession: NZ_CP102756
• Organism: Salmonella enterica subsp. enterica serovar Kentucky isolate AH19MCS11

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V3U6I8
• Locus tag: NWA04_RS06115
• Protein ID: WP_023203422.1
• Coordinates: 1280635..1280892 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	1280717..1281049 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NWA04_RS06100	1278960..1279481	+	522	WP_023203424.1	SMI1/KNR4 family protein	-
NWA04_RS06105	1279842..1280249	+	408	WP_024146273.1	DUF4329 domain-containing protein	-
NWA04_RS06110	1280268..1280576	+	309	WP_023203423.1	hypothetical protein	-
NWA04_RS06115	1280635..1280892	-	258	WP_023203422.1	SymE family type I addiction module toxin	Toxin
-	1280717..1281049	+	333	-	-	Antitoxin
NWA04_RS06120	1281965..1282240	+	276	WP_223163371.1	hypothetical protein	-
NWA04_RS06125	1282333..1282800	+	468	WP_000828182.1	sugar tyrosine-protein kinase	-
NWA04_RS06130	1283118..1283396	+	279	WP_012664366.1	hypothetical protein	-
NWA04_RS06135	1283541..1283777	-	237	Protein_1184	type I toxin-antitoxin system SymE family toxin	-
NWA04_RS06140	1283830..1284534	+	705	Protein_1185	integrase core domain-containing protein	-
NWA04_RS06145	1285295..1285792	+	498	WP_058654878.1	Saf-pilin pilus formation protein SafA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1248547..1301879	53332
	-	flank	IS/Tn	-	-	1284253..1284534	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.71 Da
• Isoelectric Point: 7.2431

>T254145 WP_023203422.1 NZ_CP102756:c1280892-1280635 [Salmonella enterica subsp. enterica serovar Kentucky]
MNASGASVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 333 bp

>AT254145 NZ_CP102756:1280717-1281049 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V3U6I8

Antitoxin