Detailed information of TA system TA254090

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 1280458..1280872
• Replicon: chromosome
• Accession: NZ_CP102739
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain AH19MCS8

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V3U6I8
• Locus tag: NWA03_RS06130
• Protein ID: WP_023203422.1
• Coordinates: 1280458..1280715 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	1280540..1280872 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NWA03_RS06115	1278783..1279304	+	522	WP_023203424.1	SMI1/KNR4 family protein	-
NWA03_RS06120	1279665..1280072	+	408	WP_024146273.1	DUF4329 domain-containing protein	-
NWA03_RS06125	1280091..1280399	+	309	WP_023203423.1	hypothetical protein	-
NWA03_RS06130	1280458..1280715	-	258	WP_023203422.1	SymE family type I addiction module toxin	Toxin
-	1280540..1280872	+	333	-	-	Antitoxin
NWA03_RS06135	1281788..1282063	+	276	WP_223163371.1	hypothetical protein	-
NWA03_RS06140	1282156..1282623	+	468	WP_000828182.1	sugar tyrosine-protein kinase	-
NWA03_RS06145	1282941..1283219	+	279	WP_012664366.1	hypothetical protein	-
NWA03_RS06150	1283364..1283600	-	237	Protein_1186	type I toxin-antitoxin system SymE family toxin	-
NWA03_RS06155	1283653..1284357	+	705	Protein_1187	integrase core domain-containing protein	-
NWA03_RS06160	1285118..1285615	+	498	WP_058654878.1	Saf-pilin pilus formation protein SafA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1248370..1304146	55776
	-	flank	IS/Tn	-	-	1284076..1284357	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.71 Da
• Isoelectric Point: 7.2431

>T254090 WP_023203422.1 NZ_CP102739:c1280715-1280458 [Salmonella enterica subsp. enterica serovar Kentucky]
MNASGASVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 333 bp

>AT254090 NZ_CP102739:1280540-1280872 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V3U6I8

Antitoxin