Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-orzP/SymE(toxin)
Location 4457958..4458370 Replicon chromosome
Accession NZ_CP102379
Organism Escherichia coli strain BM28 lysU

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag NR350_RS21605 Protein ID WP_000132601.1
Coordinates 4457958..4458299 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name orzP
Locus tag -
Coordinates 4458294..4458370 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR350_RS21590 (4454033) 4454033..4455079 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
NR350_RS21595 (4455079) 4455079..4456458 - 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
NR350_RS21600 (4456593) 4456593..4457801 + 1209 WP_001339197.1 IS4-like element ISVsa5 family transposase -
NR350_RS21605 (4457958) 4457958..4458299 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- (4458294) 4458294..4458370 + 77 NuclAT_13 - Antitoxin
- (4458294) 4458294..4458370 + 77 NuclAT_13 - Antitoxin
- (4458294) 4458294..4458370 + 77 NuclAT_13 - Antitoxin
- (4458294) 4458294..4458370 + 77 NuclAT_13 - Antitoxin
- (4458294) 4458294..4458370 + 77 NuclAT_14 - Antitoxin
- (4458294) 4458294..4458370 + 77 NuclAT_14 - Antitoxin
- (4458294) 4458294..4458370 + 77 NuclAT_14 - Antitoxin
- (4458294) 4458294..4458370 + 77 NuclAT_14 - Antitoxin
NR350_RS21610 (4458527) 4458527..4459921 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
NR350_RS21615 (4459918) 4459918..4461507 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4449535..4459921 10386
- flank IS/Tn - - 4456593..4457801 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T253558 WP_000132601.1 NZ_CP102379:c4458299-4457958 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT253558 NZ_CP102379:4458294-4458370 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References