Detailed information of TA system TA252503

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3612835..3613237
• Replicon: chromosome
• Accession: NZ_CP101689
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain SMEH

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A418Z3G0
• Locus tag: NOV91_RS17510
• Protein ID: WP_017442176.1
• Coordinates: 3612835..3613080 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3612930..3613237 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NOV91_RS17460	3608543..3609025	+	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-
NOV91_RS17465	3609078..3609305	-	228	WP_017442171.1	SymE family type I addiction module toxin	-
NOV91_RS17470	3609488..3609604	+	117	Protein_3400	RHS repeat-associated core domain-containing protein	-
NOV91_RS17475	3609719..3610000	+	282	WP_176132412.1	hypothetical protein	-
NOV91_RS17480	3609997..3610443	+	447	WP_017442172.1	hypothetical protein	-
NOV91_RS17485	3610802..3610954	+	153	WP_223195354.1	hypothetical protein	-
NOV91_RS17490	3610975..3611253	+	279	WP_197398372.1	hypothetical protein	-
NOV91_RS17495	3611255..3611833	+	579	WP_017442174.1	hypothetical protein	-
NOV91_RS17500	3612038..3612415	+	378	WP_223195355.1	HNH endonuclease	-
NOV91_RS17505	3612412..3612768	+	357	WP_017442175.1	hypothetical protein	-
NOV91_RS17510	3612835..3613080	-	246	WP_017442176.1	hypothetical protein	Toxin
-	3612930..3613237	+	308	-	-	Antitoxin
NOV91_RS17515	3613414..3613707	+	294	WP_129369132.1	hypothetical protein	-
NOV91_RS17520	3614157..3614528	+	372	WP_223195353.1	hypothetical protein	-
NOV91_RS17525	3614525..3614992	+	468	WP_017442178.1	hypothetical protein	-
NOV91_RS17530	3615310..3615588	+	279	WP_077907264.1	hypothetical protein	-
NOV91_RS17535	3615655..3615969	-	315	WP_072103451.1	SymE family type I addiction module toxin	-
NOV91_RS17540	3616022..3616180	+	159	Protein_3414	transposase	-
NOV91_RS17545	3616248..3616805	-	558	Protein_3415	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3583204..3626822	43618
	-	flank	IS/Tn	-	-	3616248..3616625	377

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8761.95 Da
• Isoelectric Point: 4.3010

>T252503 WP_017442176.1 NZ_CP101689:c3613080-3612835 [Salmonella enterica subsp. enterica serovar Mbandaka]
MNASGASVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYKAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 308 bp

>AT252503 NZ_CP101689:3612930-3613237 [Salmonella enterica subsp. enterica serovar Mbandaka]
CAATACACCCGTCCGAAATCTTCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGG
ATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGCATTCATATTTGCTGA
CTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCATGG
CACCGCGCCTCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A418Z3G0

Antitoxin