Detailed information of TA system TA252501

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3609078..3609499
• Replicon: chromosome
• Accession: NZ_CP101689
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain SMEH

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A418Z728
• Locus tag: NOV91_RS17465
• Protein ID: WP_017442171.1
• Coordinates: 3609078..3609305 (-)
• Length: 76 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3609088..3609499 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NOV91_RS17430	3604244..3604450	-	207	WP_026080916.1	SymE family type I addiction module toxin	-
NOV91_RS17435	3604444..3605697	+	1254	Protein_3393	RHS domain-containing protein	-
NOV91_RS17440	3605700..3605987	+	288	WP_017442165.1	hypothetical protein	-
NOV91_RS17445	3606056..3606190	-	135	Protein_3395	type I toxin-antitoxin system SymE family toxin	-
NOV91_RS17450	3606616..3607584	+	969	Protein_3396	polymorphic toxin type 47 domain-containing protein	-
NOV91_RS17455	3607578..3608024	+	447	WP_000935097.1	protein SciX	-
NOV91_RS17460	3608543..3609025	+	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-
NOV91_RS17465	3609078..3609305	-	228	WP_017442171.1	SymE family type I addiction module toxin	Toxin
-	3609088..3609499	+	412	-	-	Antitoxin
NOV91_RS17470	3609488..3609604	+	117	Protein_3400	RHS repeat-associated core domain-containing protein	-
NOV91_RS17475	3609719..3610000	+	282	WP_176132412.1	hypothetical protein	-
NOV91_RS17480	3609997..3610443	+	447	WP_017442172.1	hypothetical protein	-
NOV91_RS17485	3610802..3610954	+	153	WP_223195354.1	hypothetical protein	-
NOV91_RS17490	3610975..3611253	+	279	WP_197398372.1	hypothetical protein	-
NOV91_RS17495	3611255..3611833	+	579	WP_017442174.1	hypothetical protein	-
NOV91_RS17500	3612038..3612415	+	378	WP_223195355.1	HNH endonuclease	-
NOV91_RS17505	3612412..3612768	+	357	WP_017442175.1	hypothetical protein	-
NOV91_RS17510	3612835..3613080	-	246	WP_017442176.1	hypothetical protein	-
NOV91_RS17515	3613414..3613707	+	294	WP_129369132.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3583204..3626822	43618

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (5-41)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8375.51 Da
• Isoelectric Point: 6.2096

>T252501 WP_017442171.1 NZ_CP101689:c3609305-3609078 [Salmonella enterica subsp. enterica serovar Mbandaka]
MTTCYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHIKAGVNNVVNGD

Nucleotide

• Length: 228 bp

Antitoxin

Nucleotide

• Length: 412 bp

>AT252501 NZ_CP101689:3609088-3609499 [Salmonella enterica subsp. enterica serovar Mbandaka]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGTGGTCATGCAGGCTTTGCTGTTGATGTGG
CGGACGCTGACGCCGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAG
CTCAGGGCGAGCGAGTATGGGCGCGACATCCTGGCACTGCGCTCCCCTCTCCCCGGCCGGTGATGAGCAGCCGGCTGCCG
GGGCAGTATTTT

Structures

Toxin

• AlphaFold DB: A0A418Z728

Antitoxin