Detailed information of TA system TA252499

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3604244..3604450
• Replicon: chromosome
• Accession: NZ_CP101689
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain SMEH

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3Y1TUH5
• Locus tag: NOV91_RS17430
• Protein ID: WP_026080916.1
• Coordinates: 3604244..3604450 (-)
• Length: 69 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3604254..3604439 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NOV91_RS17425	3603919..3604197	+	279	WP_017442162.1	hypothetical protein	-
NOV91_RS17430	3604244..3604450	-	207	WP_026080916.1	SymE family type I addiction module toxin	Toxin
-	3604254..3604439	+	186	-	-	Antitoxin
NOV91_RS17435	3604444..3605697	+	1254	Protein_3393	RHS domain-containing protein	-
NOV91_RS17440	3605700..3605987	+	288	WP_017442165.1	hypothetical protein	-
NOV91_RS17445	3606056..3606190	-	135	Protein_3395	type I toxin-antitoxin system SymE family toxin	-
NOV91_RS17450	3606616..3607584	+	969	Protein_3396	polymorphic toxin type 47 domain-containing protein	-
NOV91_RS17455	3607578..3608024	+	447	WP_000935097.1	protein SciX	-
NOV91_RS17460	3608543..3609025	+	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-
NOV91_RS17465	3609078..3609305	-	228	WP_017442171.1	SymE family type I addiction module toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3583204..3626822	43618

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (1-34)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7592.80 Da
• Isoelectric Point: 6.4569

>T252499 WP_026080916.1 NZ_CP101689:c3604450-3604244 [Salmonella enterica subsp. enterica serovar Mbandaka]
IPELHLKGDWLAEAGFETGTSVTVKISEGCLILIAETDEVRDLRKELYLVKKSMKHIKAGVNNVVNRD

Nucleotide

• Length: 207 bp

Antitoxin

Nucleotide

• Length: 186 bp

>AT252499 NZ_CP101689:3604254-3604439 [Salmonella enterica subsp. enterica serovar Mbandaka]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCAGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCCGAGATCTTCACGGTTACGCTCGTCCCGGTCTCAAATCCCGCCT
CGGCCAGCCAGTCGCCCTTAAGATGC

Structures

Toxin

• AlphaFold DB: A0A3Y1TUH5

Antitoxin