Detailed information of TA system TA252441

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3975253..3975667
• Replicon: chromosome
• Accession: NZ_CP101648
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain BCID6

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V3U6I8
• Locus tag: NOQ95_RS19405
• Protein ID: WP_023203422.1
• Coordinates: 3975410..3975667 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3975253..3975585 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NOQ95_RS19375	3970510..3971007	-	498	WP_058654878.1	Saf-pilin pilus formation protein SafA	-
NOQ95_RS19380	3971768..3972472	-	705	Protein_3767	integrase core domain-containing protein	-
NOQ95_RS19385	3972525..3972761	+	237	Protein_3768	type I toxin-antitoxin system SymE family toxin	-
NOQ95_RS19390	3972906..3973184	-	279	WP_012664366.1	hypothetical protein	-
NOQ95_RS19395	3973502..3973969	-	468	WP_000828182.1	sugar tyrosine-protein kinase	-
NOQ95_RS19400	3974062..3974337	-	276	WP_223163371.1	hypothetical protein	-
-	3975253..3975585	-	333	-	-	Antitoxin
NOQ95_RS19405	3975410..3975667	+	258	WP_023203422.1	SymE family type I addiction module toxin	Toxin
NOQ95_RS19410	3975726..3976034	-	309	WP_023203423.1	hypothetical protein	-
NOQ95_RS19415	3976053..3976460	-	408	WP_024146273.1	DUF4329 domain-containing protein	-
NOQ95_RS19420	3976821..3977342	-	522	WP_023203424.1	SMI1/KNR4 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3954958..4007732	52774
	-	flank	IS/Tn	-	-	3971768..3972049	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.71 Da
• Isoelectric Point: 7.2431

>T252441 WP_023203422.1 NZ_CP101648:3975410-3975667 [Salmonella enterica subsp. enterica serovar Kentucky]
MNASGASVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 333 bp

>AT252441 NZ_CP101648:c3975585-3975253 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V3U6I8

Antitoxin