Detailed information of TA system TA252425

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3975232..3975646
• Replicon: chromosome
• Accession: NZ_CP101647
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain KCID6

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V3U6I8
• Locus tag: NOQ94_RS19415
• Protein ID: WP_023203422.1
• Coordinates: 3975389..3975646 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3975232..3975564 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NOQ94_RS19385	3970489..3970986	-	498	WP_058654878.1	Saf-pilin pilus formation protein SafA	-
NOQ94_RS19390	3971747..3972451	-	705	Protein_3769	integrase core domain-containing protein	-
NOQ94_RS19395	3972504..3972740	+	237	Protein_3770	type I toxin-antitoxin system SymE family toxin	-
NOQ94_RS19400	3972885..3973163	-	279	WP_012664366.1	hypothetical protein	-
NOQ94_RS19405	3973481..3973948	-	468	WP_000828182.1	sugar tyrosine-protein kinase	-
NOQ94_RS19410	3974041..3974316	-	276	WP_223163371.1	hypothetical protein	-
-	3975232..3975564	-	333	-	-	Antitoxin
NOQ94_RS19415	3975389..3975646	+	258	WP_023203422.1	SymE family type I addiction module toxin	Toxin
NOQ94_RS19420	3975705..3976013	-	309	WP_023203423.1	hypothetical protein	-
NOQ94_RS19425	3976032..3976439	-	408	WP_024146273.1	DUF4329 domain-containing protein	-
NOQ94_RS19430	3976800..3977321	-	522	WP_023203424.1	SMI1/KNR4 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3954938..4007710	52772
	-	flank	IS/Tn	-	-	3971747..3972028	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.71 Da
• Isoelectric Point: 7.2431

>T252425 WP_023203422.1 NZ_CP101647:3975389-3975646 [Salmonella enterica subsp. enterica serovar Kentucky]
MNASGASVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 333 bp

>AT252425 NZ_CP101647:c3975564-3975232 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V3U6I8

Antitoxin