Detailed information of TA system TA251934

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3760469..3760871
• Replicon: chromosome
• Accession: NZ_CP101369
• Organism: Salmonella enterica strain SC2014238

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V9E7A9
• Locus tag: NMU30_RS18900
• Protein ID: WP_023216760.1
• Coordinates: 3760626..3760871 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3760469..3760835 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NMU30_RS18875	3756864..3757460	+	597	Protein_3632	ATP-binding protein	-
NMU30_RS18880	3757500..3757686	-	187	Protein_3633	transposase	-
NMU30_RS18885	3757739..3757987	+	249	WP_023216986.1	SymE family type I addiction module toxin	-
NMU30_RS18890	3758119..3758396	-	278	Protein_3635	hypothetical protein	-
NMU30_RS18895	3758714..3759181	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
-	3760469..3760835	-	367	-	-	Antitoxin
NMU30_RS18900	3760626..3760871	+	246	WP_023216760.1	hypothetical protein	Toxin
NMU30_RS18905	3760930..3761238	-	309	WP_023216761.1	hypothetical protein	-
NMU30_RS18910	3761257..3761634	-	378	WP_024147216.1	DUF4329 domain-containing protein	-
NMU30_RS18915	3762025..3762546	-	522	WP_023203424.1	SMI1/KNR4 family protein	-
NMU30_RS18920	3762560..3762640	-	81	WP_079940869.1	HNH endonuclease	-
NMU30_RS18925	3762941..3763753	-	813	Protein_3642	RHS domain-containing protein	-
NMU30_RS18930	3763895..3764476	-	582	WP_240890592.1	hypothetical protein	-
NMU30_RS18935	3764479..3764739	-	261	WP_023216764.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3747708..3768810	21102

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8791.93 Da
• Isoelectric Point: 4.1428

>T251934 WP_023216760.1 NZ_CP101369:3760626-3760871 [Salmonella enterica]
MNASGASVRHINSETCMTTCYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 367 bp

>AT251934 NZ_CP101369:c3760835-3760469 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGTGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCG
GCCAGTACCGGGCGGTGATGAGCAACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V9E7A9

Antitoxin