Detailed information of TA system TA251913

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3692878..3693228
• Replicon: chromosome
• Accession: NZ_CP101365
• Organism: Salmonella enterica strain SC2014107

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3X9ZUV0
• Locus tag: NM059_RS18210
• Protein ID: WP_000994229.1
• Coordinates: 3692971..3693228 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3692878..3693146 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NM059_RS18170	3687918..3688622	-	705	Protein_3555	integrase core domain-containing protein	-
NM059_RS18175	3688675..3688923	+	249	WP_001738030.1	SymE family type I addiction module toxin	-
NM059_RS18180	3689055..3689333	-	279	WP_079798501.1	hypothetical protein	-
NM059_RS18185	3689416..3689532	-	117	WP_227457392.1	hypothetical protein	-
NM059_RS18190	3689774..3690031	+	258	WP_079798500.1	SymE family type I addiction module toxin	-
NM059_RS18195	3690122..3690499	-	378	WP_000739707.1	Imm8 family immunity protein	-
NM059_RS18200	3691232..3691597	-	366	WP_001231281.1	hypothetical protein	-
NM059_RS18205	3691563..3692909	-	1347	Protein_3562	RHS domain-containing protein	-
-	3692878..3693146	-	269	-	-	Antitoxin
NM059_RS18210	3692971..3693228	+	258	WP_000994229.1	SymE family type I addiction module toxin	Toxin
NM059_RS18215	3693292..3693630	-	339	WP_000382983.1	hypothetical protein	-
NM059_RS18220	3694001..3695758	-	1758	Protein_3565	RHS repeat protein	-
NM059_RS18225	3695963..3696196	+	234	WP_000035941.1	hypothetical protein	-
NM059_RS18230	3696268..3696615	-	348	WP_000887296.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3669430..3696639	27209
	-	flank	IS/Tn	-	-	3687918..3688199	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9538.91 Da
• Isoelectric Point: 7.2759

>T251913 WP_000994229.1 NZ_CP101365:3692971-3693228 [Salmonella enterica]
MNASGVSVRHINSKTHMTTYYSQIPSLHLKGDWLEEAGFETGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 269 bp

>AT251913 NZ_CP101365:c3693146-3692878 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCCGCGCCCGGTCTCAAATCCCGCTTCTTCCAGCCA
GTCACCCTTAAGGTGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGAGCGCGACAGCCTGCACCG

Structures

Toxin

• AlphaFold DB: A0A3X9ZUV0

Antitoxin