Detailed information of TA system TA251911

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3689617..3690031
• Replicon: chromosome
• Accession: NZ_CP101365
• Organism: Salmonella enterica strain SC2014107

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: NM059_RS18190
• Protein ID: WP_079798500.1
• Coordinates: 3689774..3690031 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3689617..3689949 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NM059_RS18160	3685846..3686583	-	738	WP_001750707.1	pili assembly chaperone SafB	-
NM059_RS18165	3686660..3687157	-	498	WP_001750706.1	Saf-pilin pilus formation protein SafA	-
NM059_RS18170	3687918..3688622	-	705	Protein_3555	integrase core domain-containing protein	-
NM059_RS18175	3688675..3688923	+	249	WP_001738030.1	SymE family type I addiction module toxin	-
NM059_RS18180	3689055..3689333	-	279	WP_079798501.1	hypothetical protein	-
NM059_RS18185	3689416..3689532	-	117	WP_227457392.1	hypothetical protein	-
-	3689617..3689949	-	333	-	-	Antitoxin
NM059_RS18190	3689774..3690031	+	258	WP_079798500.1	SymE family type I addiction module toxin	Toxin
NM059_RS18195	3690122..3690499	-	378	WP_000739707.1	Imm8 family immunity protein	-
NM059_RS18200	3691232..3691597	-	366	WP_001231281.1	hypothetical protein	-
NM059_RS18205	3691563..3692909	-	1347	Protein_3562	RHS domain-containing protein	-
NM059_RS18210	3692971..3693228	+	258	WP_000994229.1	SymE family type I addiction module toxin	-
NM059_RS18215	3693292..3693630	-	339	WP_000382983.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3669430..3696639	27209
	-	flank	IS/Tn	-	-	3687918..3688199	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9547.82 Da
• Isoelectric Point: 5.0770

>T251911 WP_079798500.1 NZ_CP101365:3689774-3690031 [Salmonella enterica]
MNASGVSVRHINSETCMSACYSQIPSQHLKGDWQEEAGFETGRSITVKISQECIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 333 bp

>AT251911 NZ_CP101365:c3689949-3689617 [Salmonella enterica]
TCCGCCATCAGCACAATACACTCCTGTGAAATCTTCACGGTGATGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGACATGCAGGTTTCGCTGTTGATATGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCAGCCGGCTGCC
GGGGCCGTATTTT

Structures

Antitoxin