Detailed information of TA system TA251292

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3618026..3618440
• Replicon: chromosome
• Accession: NZ_CP100736
• Organism: Salmonella enterica subsp. enterica serovar Agona strain R18.1477

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: B5F8Y1
• Locus tag: NL742_RS17515
• Protein ID: WP_000994221.1
• Coordinates: 3618183..3618440 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3618026..3618404 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NL742_RS17485	3613349..3613846	-	498	WP_000835844.1	Saf-pilin pilus formation protein SafA	-
NL742_RS17490	3614607..3615311	-	705	Protein_3422	integrase core domain-containing protein	-
NL742_RS17495	3615395..3615544	+	150	WP_151273333.1	type I toxin-antitoxin system SymE family toxin	-
NL742_RS17500	3615676..3615954	-	279	WP_077905764.1	hypothetical protein	-
NL742_RS17505	3616272..3616739	-	468	WP_000828177.1	sugar tyrosine-protein kinase	-
NL742_RS17510	3617556..3617975	-	420	WP_130549555.1	hypothetical protein	-
-	3618026..3618404	-	379	-	-	Antitoxin
NL742_RS17515	3618183..3618440	+	258	WP_000994221.1	SymE family type I addiction module toxin	Toxin
NL742_RS17520	3618507..3618938	-	432	WP_000778606.1	hypothetical protein	-
NL742_RS17525	3619010..3619426	-	417	WP_001748027.1	DUF2195 family protein	-
NL742_RS17530	3619423..3619791	-	369	Protein_3430	hypothetical protein	-
NL742_RS17535	3619790..3619855	+	66	Protein_3431	hypothetical protein	-
NL742_RS17540	3620105..3620290	-	186	Protein_3432	transposase	-
NL742_RS17545	3620390..3621061	-	672	WP_000058649.1	ankyrin repeat domain-containing protein	-
NL742_RS17550	3621077..3621562	-	486	WP_000103455.1	hypothetical protein	-
NL742_RS17555	3621904..3622140	+	237	WP_130549554.1	hypothetical protein	-
NL742_RS17560	3622222..3622398	+	177	Protein_3436	hypothetical protein	-
NL742_RS17565	3622866..3623228	-	363	WP_001748026.1	Arm DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3605451..3623228	17777

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9356.66 Da
• Isoelectric Point: 5.6373

>T251292 WP_000994221.1 NZ_CP100736:3618183-3618440 [Salmonella enterica subsp. enterica serovar Agona]
MNASGVSVRHINSETCITTCYSQIPSQHLKGDWQEEAGFETGRSVTVKISQGCIVLMADGNEVQKLCEQLYQAERVVKGL
KDVLV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 379 bp

>AT251292 NZ_CP100736:c3618404-3618026 [Salmonella enterica subsp. enterica serovar Agona]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCCTGTGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAG
TAACAGGTGGTTATACAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAA
TTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCC
CCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3L1ZDZ2

Antitoxin