Detailed information of TA system TA251249

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3738759..3739191
• Replicon: chromosome
• Accession: NZ_CP100728
• Organism: Salmonella enterica subsp. enterica serovar Blockley strain R17.0776

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5T4YU52
• Locus tag: NL731_RS18540
• Protein ID: WP_064047498.1
• Coordinates: 3738916..3739191 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3738759..3739181 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NL731_RS18505	3734010..3734507	-	498	WP_064047504.1	pilus assembly protein	-
NL731_RS18510	3735272..3735973	-	702	Protein_3625	integrase core domain-containing protein	-
NL731_RS18515	3736026..3736340	+	315	WP_074180621.1	SymE family type I addiction module toxin	-
NL731_RS18520	3736407..3736685	-	279	WP_077906154.1	hypothetical protein	-
NL731_RS18525	3737003..3737470	-	468	WP_023221536.1	hypothetical protein	-
NL731_RS18530	3737563..3737838	-	276	WP_225737025.1	hypothetical protein	-
NL731_RS18535	3738288..3738581	-	294	WP_125854225.1	hypothetical protein	-
-	3738759..3739181	-	423	-	-	Antitoxin
NL731_RS18540	3738916..3739191	+	276	WP_064047498.1	SymE family type I addiction module toxin	Toxin
NL731_RS18545	3739248..3739580	-	333	WP_001750702.1	barstar family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3726110..3739580	13470
	-	flank	IS/Tn	-	-	3735272..3735550	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (12-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 9855.16 Da
• Isoelectric Point: 6.6996

>T251249 WP_064047498.1 NZ_CP100728:3738916-3739191 [Salmonella enterica subsp. enterica serovar Blockley]
MNASGASVRHINSETCMTACYSQIPSQHLKGDWLAEAGFDTGASVTVKSSEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNDVVNGN

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 423 bp

>AT251249 NZ_CP100728:c3739181-3738759 [Salmonella enterica subsp. enterica serovar Blockley]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGCTCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGGCGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCA
ACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5T4YU52

Antitoxin