Detailed information of TA system TA251203

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3814543..3814945
• Replicon: chromosome
• Accession: NZ_CP100718
• Organism: Salmonella enterica subsp. enterica serovar Weltevreden strain R17.4942

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5X0DP36
• Locus tag: NL732_RS18755
• Protein ID: WP_000994222.1
• Coordinates: 3814700..3814945 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3814543..3814909 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NL732_RS18725	3809809..3810306	-	498	WP_000800123.1	hypothetical protein	-
NL732_RS18730	3811062..3811766	-	705	Protein_3669	integrase core domain-containing protein	-
NL732_RS18735	3811819..3812067	+	249	WP_023165496.1	SymE family type I addiction module toxin	-
NL732_RS18740	3812199..3812477	-	279	WP_077677834.1	hypothetical protein	-
NL732_RS18745	3812794..3813261	-	468	WP_000828179.1	sugar tyrosine-protein kinase	-
NL732_RS18750	3814133..3814366	-	234	WP_124084119.1	hypothetical protein	-
-	3814543..3814909	-	367	-	-	Antitoxin
NL732_RS18755	3814700..3814945	+	246	WP_000994222.1	hypothetical protein	Toxin
NL732_RS18760	3815012..3815443	-	432	WP_000778607.1	hypothetical protein	-
NL732_RS18765	3815445..3818300	-	2856	Protein_3676	RHS domain-containing protein	-
NL732_RS18770	3818291..3818581	+	291	WP_015632802.1	SymE family type I addiction module toxin	-
NL732_RS18775	3818719..3819186	-	468	WP_000343595.1	Imm9 family immunity protein	-
NL732_RS18780	3819206..3819547	-	342	WP_024134110.1	RHS repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3801917..3844343	42426
	-	flank	IS/Tn	-	-	3811062..3811343	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8822.02 Da
• Isoelectric Point: 4.1428

>T251203 WP_000994222.1 NZ_CP100718:3814700-3814945 [Salmonella enterica subsp. enterica serovar Weltevreden]
MNASGVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDMI
V

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 367 bp

>AT251203 NZ_CP100718:c3814909-3814543 [Salmonella enterica subsp. enterica serovar Weltevreden]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCG
GCCAGTACCGGGCGGTGATGAGCAACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5X0DP36

Antitoxin