Detailed information of TA system TA251165

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3706161..3706593
• Replicon: chromosome
• Accession: NZ_CP100710
• Organism: Salmonella enterica subsp. enterica serovar Blockley strain R18.0186

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5T4YU52
• Locus tag: NL733_RS18300
• Protein ID: WP_064047498.1
• Coordinates: 3706318..3706593 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3706161..3706583 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NL733_RS18265	3701412..3701909	-	498	WP_064047504.1	pilus assembly protein	-
NL733_RS18270	3702674..3703375	-	702	Protein_3577	integrase core domain-containing protein	-
NL733_RS18275	3703428..3703742	+	315	WP_074180621.1	SymE family type I addiction module toxin	-
NL733_RS18280	3703809..3704087	-	279	WP_077906154.1	hypothetical protein	-
NL733_RS18285	3704405..3704872	-	468	WP_023221536.1	hypothetical protein	-
NL733_RS18290	3704965..3705240	-	276	WP_225737025.1	hypothetical protein	-
NL733_RS18295	3705690..3705983	-	294	WP_125854225.1	hypothetical protein	-
-	3706161..3706583	-	423	-	-	Antitoxin
NL733_RS18300	3706318..3706593	+	276	WP_064047498.1	SymE family type I addiction module toxin	Toxin
NL733_RS18305	3706650..3706982	-	333	WP_001750702.1	barstar family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3693512..3706982	13470
	-	flank	IS/Tn	-	-	3702674..3702952	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (12-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 9855.16 Da
• Isoelectric Point: 6.6996

>T251165 WP_064047498.1 NZ_CP100710:3706318-3706593 [Salmonella enterica subsp. enterica serovar Blockley]
MNASGASVRHINSETCMTACYSQIPSQHLKGDWLAEAGFDTGASVTVKSSEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNDVVNGN

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 423 bp

>AT251165 NZ_CP100710:c3706583-3706161 [Salmonella enterica subsp. enterica serovar Blockley]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGCTCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGGCGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCA
ACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5T4YU52

Antitoxin