Detailed information of TA system TA251075

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3775339..3775741
• Replicon: chromosome
• Accession: NZ_CP100695
• Organism: Salmonella enterica subsp. enterica serovar Weltevreden strain R18.0830

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5X0DP36
• Locus tag: NL711_RS18605
• Protein ID: WP_000994222.1
• Coordinates: 3775496..3775741 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3775339..3775705 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NL711_RS18575	3770605..3771102	-	498	WP_000800123.1	hypothetical protein	-
NL711_RS18580	3771858..3772562	-	705	Protein_3638	integrase core domain-containing protein	-
NL711_RS18585	3772615..3772863	+	249	WP_023165496.1	SymE family type I addiction module toxin	-
NL711_RS18590	3772995..3773273	-	279	WP_077677834.1	hypothetical protein	-
NL711_RS18595	3773590..3774057	-	468	WP_000828179.1	sugar tyrosine-protein kinase	-
NL711_RS18600	3774929..3775162	-	234	WP_124084119.1	hypothetical protein	-
-	3775339..3775705	-	367	-	-	Antitoxin
NL711_RS18605	3775496..3775741	+	246	WP_000994222.1	hypothetical protein	Toxin
NL711_RS18610	3775808..3776239	-	432	WP_000778607.1	hypothetical protein	-
NL711_RS18615	3776241..3779096	-	2856	Protein_3645	RHS domain-containing protein	-
NL711_RS18620	3779087..3779377	+	291	WP_015632802.1	SymE family type I addiction module toxin	-
NL711_RS18625	3779515..3779982	-	468	WP_000343595.1	Imm9 family immunity protein	-
NL711_RS18630	3780002..3780343	-	342	WP_024134110.1	RHS repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3762713..3805139	42426
	-	flank	IS/Tn	-	-	3771858..3772139	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8822.02 Da
• Isoelectric Point: 4.1428

>T251075 WP_000994222.1 NZ_CP100695:3775496-3775741 [Salmonella enterica subsp. enterica serovar Weltevreden]
MNASGVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDMI
V

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 367 bp

>AT251075 NZ_CP100695:c3775705-3775339 [Salmonella enterica subsp. enterica serovar Weltevreden]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCG
GCCAGTACCGGGCGGTGATGAGCAACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5X0DP36

Antitoxin