Detailed information of TA system TA251059

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3612550..3612982
• Replicon: chromosome
• Accession: NZ_CP100693
• Organism: Salmonella enterica subsp. enterica serovar London strain R18.1595

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5H8VGI7
• Locus tag: NL712_RS17630
• Protein ID: WP_058805824.1
• Coordinates: 3612707..3612982 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3612550..3612931 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NL712_RS17600	3607813..3608307	-	495	WP_187788956.1	pilus assembly protein	-
NL712_RS17605	3609072..3609773	-	702	Protein_3446	integrase core domain-containing protein	-
NL712_RS17610	3609826..3610140	+	315	WP_011233128.1	SymE family type I addiction module toxin	-
NL712_RS17615	3610207..3610485	-	279	WP_077905025.1	hypothetical protein	-
NL712_RS17620	3610801..3611268	-	468	WP_000828173.1	sugar tyrosine-protein kinase	-
NL712_RS17625	3612140..3612373	-	234	WP_129374720.1	hypothetical protein	-
-	3612550..3612931	-	382	-	-	Antitoxin
NL712_RS17630	3612707..3612982	+	276	WP_058805824.1	SymE family type I addiction module toxin	Toxin
NL712_RS17635	3613027..3613344	-	318	WP_129374721.1	hypothetical protein	-
NL712_RS17640	3613310..3614593	-	1284	Protein_3453	RHS domain-containing protein	-
NL712_RS17645	3614730..3615194	-	465	WP_223152163.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3602739..3640874	38135

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 9901.27 Da
• Isoelectric Point: 5.0770

>T251059 WP_058805824.1 NZ_CP100693:3612707-3612982 [Salmonella enterica subsp. enterica serovar London]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWLAEAGFDTGASVTVKSSEGCLTLIAERDEVQELREELYQVKQVVKGM
KVGISGVLREV

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 382 bp

>AT251059 NZ_CP100693:c3612931-3612550 [Salmonella enterica subsp. enterica serovar London]
CTGTTTAACCTGATAAAGTTCCTCCCGCAGCTCCTGCACCTCGTCGCGCTCCGCAATCAGAGTCAAACACCCCTCGGAGC
TCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTTCTGCCAGCCAGTCGCCCTTAAGGTGCTGGCTGGGGATTTGT
GAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAAT
AAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGC
GCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5H8VGI7

Antitoxin