Detailed information of TA system TA251027

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3620985..3621407
• Replicon: chromosome
• Accession: NZ_CP100689
• Organism: Salmonella enterica subsp. enterica serovar Newport strain R18.0287

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V6CTL5
• Locus tag: FGU70_RS17645
• Protein ID: WP_000994227.1
• Coordinates: 3621132..3621407 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3620985..3621397 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGU70_RS17620	3616243..3616737	-	495	WP_000839693.1	Saf-pilin pilus formation protein SafA	-
FGU70_RS17625	3617498..3618202	-	705	Protein_3446	integrase core domain-containing protein	-
FGU70_RS17630	3618255..3618569	+	315	WP_001539118.1	SymE family type I addiction module toxin	-
FGU70_RS17635	3618636..3618914	-	279	WP_077905025.1	hypothetical protein	-
FGU70_RS17640	3619230..3619697	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
-	3620985..3621397	-	413	-	-	Antitoxin
FGU70_RS17645	3621132..3621407	+	276	WP_000994227.1	SymE family type I addiction module toxin	Toxin
FGU70_RS17650	3621455..3621886	-	432	WP_000778566.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3611167..3642991	31824

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10090.38 Da
• Isoelectric Point: 6.8602

>T251027 WP_000994227.1 NZ_CP100689:3621132-3621407 [Salmonella enterica subsp. enterica serovar Newport]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEDAGFETGRSVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Nucleotide

• Length: 276 bp

Antitoxin

Nucleotide

• Length: 413 bp

>AT251027 NZ_CP100689:c3621397-3620985 [Salmonella enterica subsp. enterica serovar Newport]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAAATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCGT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACTGTGCCCCCCTCTCCCCGGCCAGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V6CTL5

Antitoxin