Detailed information of TA system TA250996

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3496204..3496596
• Replicon: chromosome
• Accession: NZ_CP100682
• Organism: Salmonella enterica subsp. enterica serovar Goldcoast strain R18.0450

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V9S8T1
• Locus tag: FC623_RS16865
• Protein ID: WP_000994223.1
• Coordinates: 3496351..3496596 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3496204..3496560 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FC623_RS16835	3491456..3491953	-	498	WP_165963407.1	pilus assembly protein	-
FC623_RS16840	3492715..3493419	-	705	Protein_3295	integrase core domain-containing protein	-
FC623_RS16845	3493472..3493786	+	315	WP_133322996.1	SymE family type I addiction module toxin	-
FC623_RS16850	3493853..3494131	-	279	WP_133323248.1	hypothetical protein	-
FC623_RS16855	3494449..3494916	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
FC623_RS16860	3495734..3496153	-	420	WP_131040133.1	hypothetical protein	-
-	3496204..3496560	-	357	-	-	Antitoxin
FC623_RS16865	3496351..3496596	+	246	WP_000994223.1	hypothetical protein	Toxin
FC623_RS16870	3496663..3497205	-	543	WP_079984650.1	hypothetical protein	-
FC623_RS16875	3497205..3501311	-	4107	WP_133322998.1	RHS repeat-associated core domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3483551..3497205	13654

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8789.96 Da
• Isoelectric Point: 4.1428

>T250996 WP_000994223.1 NZ_CP100682:3496351-3496596 [Salmonella enterica subsp. enterica serovar Goldcoast]
MNASGVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 357 bp

>AT250996 NZ_CP100682:c3496560-3496204 [Salmonella enterica subsp. enterica serovar Goldcoast]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V9S8T1

Antitoxin