Detailed information of TA system TA250949

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 970960..971362
• Replicon: chromosome
• Accession: NZ_CP100670
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain R17.0904

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A418Z3G0
• Locus tag: NL713_RS04560
• Protein ID: WP_017442176.1
• Coordinates: 970960..971205 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	971055..971362 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NL713_RS04510	966668..967150	+	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-
NL713_RS04515	967203..967430	-	228	WP_017442171.1	SymE family type I addiction module toxin	-
NL713_RS04520	967613..967729	+	117	Protein_875	RHS repeat-associated core domain-containing protein	-
NL713_RS04525	967844..968125	+	282	WP_176132412.1	hypothetical protein	-
NL713_RS04530	968122..968568	+	447	WP_017442172.1	hypothetical protein	-
NL713_RS04535	968927..969079	+	153	WP_223195354.1	hypothetical protein	-
NL713_RS04540	969100..969378	+	279	WP_197398372.1	hypothetical protein	-
NL713_RS04545	969380..969958	+	579	WP_017442174.1	hypothetical protein	-
NL713_RS04550	970163..970540	+	378	WP_223195355.1	HNH endonuclease	-
NL713_RS04555	970537..970893	+	357	WP_017442175.1	hypothetical protein	-
NL713_RS04560	970960..971205	-	246	WP_017442176.1	hypothetical protein	Toxin
-	971055..971362	+	308	-	-	Antitoxin
NL713_RS04565	971539..971832	+	294	WP_129369132.1	hypothetical protein	-
NL713_RS04570	972282..972653	+	372	WP_223195353.1	hypothetical protein	-
NL713_RS04575	972650..973117	+	468	WP_017442178.1	hypothetical protein	-
NL713_RS04580	973435..973713	+	279	WP_077907264.1	hypothetical protein	-
NL713_RS04585	973780..974094	-	315	WP_072103451.1	SymE family type I addiction module toxin	-
NL713_RS04590	974147..974305	+	159	Protein_889	transposase	-
NL713_RS04595	974373..974930	-	558	Protein_890	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	941329..984946	43617
	-	flank	IS/Tn	-	-	974373..974750	377

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8761.95 Da
• Isoelectric Point: 4.3010

>T250949 WP_017442176.1 NZ_CP100670:c971205-970960 [Salmonella enterica subsp. enterica serovar Mbandaka]
MNASGASVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYKAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 308 bp

>AT250949 NZ_CP100670:971055-971362 [Salmonella enterica subsp. enterica serovar Mbandaka]
CAATACACCCGTCCGAAATCTTCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGG
ATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGCATTCATATTTGCTGA
CTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCATGG
CACCGCGCCTCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A418Z3G0

Antitoxin