Detailed information of TA system TA250947

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 967203..967624
• Replicon: chromosome
• Accession: NZ_CP100670
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain R17.0904

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A418Z728
• Locus tag: NL713_RS04515
• Protein ID: WP_017442171.1
• Coordinates: 967203..967430 (-)
• Length: 76 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	967213..967624 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NL713_RS04480	962369..962575	-	207	WP_026080916.1	SymE family type I addiction module toxin	-
NL713_RS04485	962569..963822	+	1254	Protein_868	RHS domain-containing protein	-
NL713_RS04490	963825..964112	+	288	WP_017442165.1	hypothetical protein	-
NL713_RS04495	964181..964315	-	135	Protein_870	type I toxin-antitoxin system SymE family toxin	-
NL713_RS04500	964741..965709	+	969	Protein_871	polymorphic toxin type 47 domain-containing protein	-
NL713_RS04505	965703..966149	+	447	WP_000935097.1	protein SciX	-
NL713_RS04510	966668..967150	+	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-
NL713_RS04515	967203..967430	-	228	WP_017442171.1	SymE family type I addiction module toxin	Toxin
-	967213..967624	+	412	-	-	Antitoxin
NL713_RS04520	967613..967729	+	117	Protein_875	RHS repeat-associated core domain-containing protein	-
NL713_RS04525	967844..968125	+	282	WP_176132412.1	hypothetical protein	-
NL713_RS04530	968122..968568	+	447	WP_017442172.1	hypothetical protein	-
NL713_RS04535	968927..969079	+	153	WP_223195354.1	hypothetical protein	-
NL713_RS04540	969100..969378	+	279	WP_197398372.1	hypothetical protein	-
NL713_RS04545	969380..969958	+	579	WP_017442174.1	hypothetical protein	-
NL713_RS04550	970163..970540	+	378	WP_223195355.1	HNH endonuclease	-
NL713_RS04555	970537..970893	+	357	WP_017442175.1	hypothetical protein	-
NL713_RS04560	970960..971205	-	246	WP_017442176.1	hypothetical protein	-
NL713_RS04565	971539..971832	+	294	WP_129369132.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	941329..984946	43617

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (5-41)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8375.51 Da
• Isoelectric Point: 6.2096

>T250947 WP_017442171.1 NZ_CP100670:c967430-967203 [Salmonella enterica subsp. enterica serovar Mbandaka]
MTTCYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHIKAGVNNVVNGD

Nucleotide

• Length: 228 bp

Antitoxin

Nucleotide

• Length: 412 bp

>AT250947 NZ_CP100670:967213-967624 [Salmonella enterica subsp. enterica serovar Mbandaka]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGTGGTCATGCAGGCTTTGCTGTTGATGTGG
CGGACGCTGACGCCGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAG
CTCAGGGCGAGCGAGTATGGGCGCGACATCCTGGCACTGCGCTCCCCTCTCCCCGGCCGGTGATGAGCAGCCGGCTGCCG
GGGCAGTATTTT

Structures

Toxin

• AlphaFold DB: A0A418Z728

Antitoxin