Detailed information of TA system TA250945

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 962369..962575
• Replicon: chromosome
• Accession: NZ_CP100670
• Organism: Salmonella enterica subsp. enterica serovar Mbandaka strain R17.0904

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3Y1TUH5
• Locus tag: NL713_RS04480
• Protein ID: WP_026080916.1
• Coordinates: 962369..962575 (-)
• Length: 69 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	962379..962564 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NL713_RS04475	962044..962322	+	279	WP_017442162.1	hypothetical protein	-
NL713_RS04480	962369..962575	-	207	WP_026080916.1	SymE family type I addiction module toxin	Toxin
-	962379..962564	+	186	-	-	Antitoxin
NL713_RS04485	962569..963822	+	1254	Protein_868	RHS domain-containing protein	-
NL713_RS04490	963825..964112	+	288	WP_017442165.1	hypothetical protein	-
NL713_RS04495	964181..964315	-	135	Protein_870	type I toxin-antitoxin system SymE family toxin	-
NL713_RS04500	964741..965709	+	969	Protein_871	polymorphic toxin type 47 domain-containing protein	-
NL713_RS04505	965703..966149	+	447	WP_000935097.1	protein SciX	-
NL713_RS04510	966668..967150	+	483	WP_017442170.1	immunity 26/phosphotriesterase HocA family protein	-
NL713_RS04515	967203..967430	-	228	WP_017442171.1	SymE family type I addiction module toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	941329..984946	43617

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (1-34)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7592.80 Da
• Isoelectric Point: 6.4569

>T250945 WP_026080916.1 NZ_CP100670:c962575-962369 [Salmonella enterica subsp. enterica serovar Mbandaka]
IPELHLKGDWLAEAGFETGTSVTVKISEGCLILIAETDEVRDLRKELYLVKKSMKHIKAGVNNVVNRD

Nucleotide

• Length: 207 bp

Antitoxin

Nucleotide

• Length: 186 bp

>AT250945 NZ_CP100670:962379-962564 [Salmonella enterica subsp. enterica serovar Mbandaka]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCAGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCCGAGATCTTCACGGTTACGCTCGTCCCGGTCTCAAATCCCGCCT
CGGCCAGCCAGTCGCCCTTAAGATGC

Structures

Toxin

• AlphaFold DB: A0A3Y1TUH5

Antitoxin