Detailed information of TA system TA248139

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3692822..3693073
• Replicon: chromosome
• Accession: NZ_CP098831
• Organism: Salmonella enterica subsp. enterica serovar Indiana strain YZ20MCS14

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: NFH10_RS18380
• Protein ID: WP_131166435.1
• Coordinates: 3692822..3693073 (+)
• Length: 84 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3692838..3693063 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NFH10_RS18360	3689350..3690090	-	741	WP_051129375.1	pili assembly chaperone SafB	-
NFH10_RS18365	3690165..3690662	-	498	WP_051129374.1	Saf-pilin pilus formation protein SafA	-
NFH10_RS18370	3690795..3691289	-	495	WP_051129373.1	hypothetical protein	-
NFH10_RS18375	3692057..3692758	-	702	Protein_3604	integrase core domain-containing protein	-
NFH10_RS18380	3692822..3693073	+	252	WP_131166435.1	SymE family type I addiction module toxin	Toxin
-	3692838..3693063	-	226	-	-	Antitoxin
NFH10_RS18385	3693119..3693583	-	465	WP_127201574.1	hypothetical protein	-
NFH10_RS18390	3693964..3694809	-	846	Protein_3607	RHS repeat-associated core domain-containing protein	-
NFH10_RS18395	3694829..3694966	+	138	WP_023227287.1	hypothetical protein	-
NFH10_RS18400	3695109..3695717	-	609	WP_053505599.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3672954..3717269	44315
	-	flank	IS/Tn	-	-	3692057..3692335	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (10-48)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9451.82 Da
• Isoelectric Point: 8.0365

>T248139 WP_131166435.1 NZ_CP098831:3692822-3693073 [Salmonella enterica subsp. enterica serovar Indiana]
MRDTYKTHMTTYYSRIPSLHLKGDWLAEAGFDTGASVTVKISEGCLTLIVETDEVRDLRRELYQVKKSMKHIKAGVYDVV
NGN

Nucleotide

• Length: 252 bp

Antitoxin

Nucleotide

• Length: 226 bp

>AT248139 NZ_CP098831:c3693063-3692838 [Salmonella enterica subsp. enterica serovar Indiana]
TTCACCACATCATATACCCCCGCCTTAATGTGCTTCATCGACTTTTTCACCTGATAAAGCTCCCTCCGTAGATCCCTCAC
TTCGTCTGTCTCCACAATCAGAGTCAAACACCCTTCGGAGATCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCAGGCTGGGGATGCGCGAGTAATAGGTGGTCATGTGGGTTT

Structures

Antitoxin