Detailed information of TA system TA248125

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3804169..3804420
• Replicon: chromosome
• Accession: NZ_CP098829
• Organism: Salmonella enterica subsp. enterica serovar Indiana strain YZ20MCS6

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: NFG92_RS18910
• Protein ID: WP_131166435.1
• Coordinates: 3804169..3804420 (+)
• Length: 84 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3804185..3804410 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NFG92_RS18880	3799361..3800101	-	741	WP_051129375.1	pili assembly chaperone SafB	-
NFG92_RS18885	3800176..3800673	-	498	WP_051129374.1	Saf-pilin pilus formation protein SafA	-
NFG92_RS18890	3800806..3801300	-	495	WP_051129373.1	hypothetical protein	-
NFG92_RS18895	3802068..3802614	-	547	Protein_3706	integrase core domain-containing protein	-
NFG92_RS18900	3802705..3803933	+	1229	WP_089541817.1	IS3 family transposase	-
NFG92_RS18905	3803959..3804105	-	147	Protein_3708	transposase	-
NFG92_RS18910	3804169..3804420	+	252	WP_131166435.1	SymE family type I addiction module toxin	Toxin
-	3804185..3804410	-	226	-	-	Antitoxin
NFG92_RS18915	3804466..3804930	-	465	WP_127201574.1	hypothetical protein	-
NFG92_RS18920	3805311..3806156	-	846	Protein_3711	RHS repeat-associated core domain-containing protein	-
NFG92_RS18925	3806176..3806313	+	138	WP_023227287.1	hypothetical protein	-
NFG92_RS18930	3806456..3807064	-	609	WP_053505599.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3782965..3828616	45651

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (10-48)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9451.82 Da
• Isoelectric Point: 8.0365

>T248125 WP_131166435.1 NZ_CP098829:3804169-3804420 [Salmonella enterica subsp. enterica serovar Indiana]
MRDTYKTHMTTYYSRIPSLHLKGDWLAEAGFDTGASVTVKISEGCLTLIVETDEVRDLRRELYQVKKSMKHIKAGVYDVV
NGN

Nucleotide

• Length: 252 bp

Antitoxin

Nucleotide

• Length: 226 bp

>AT248125 NZ_CP098829:c3804410-3804185 [Salmonella enterica subsp. enterica serovar Indiana]
TTCACCACATCATATACCCCCGCCTTAATGTGCTTCATCGACTTTTTCACCTGATAAAGCTCCCTCCGTAGATCCCTCAC
TTCGTCTGTCTCCACAATCAGAGTCAAACACCCTTCGGAGATCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCAGGCTGGGGATGCGCGAGTAATAGGTGGTCATGTGGGTTT

Structures

Antitoxin