Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 489240..489735 Replicon chromosome
Accession NC_014228
Organism Xenorhabdus nematophila ATCC 19061

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag XNC1_RS22085 Protein ID WP_081480213.1
Coordinates 489541..489735 (-) Length 65 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag XNC1_RS02470 Protein ID WP_010848973.1
Coordinates 489240..489539 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XNC1_RS02455 (XNC1_0565) 484829..486262 + 1434 WP_013183340.1 NAD-dependent succinate-semialdehyde dehydrogenase -
XNC1_RS20955 486287..486469 - 183 Protein_470 transposase -
XNC1_RS02460 (XNC1_0566) 486526..487668 + 1143 WP_013183341.1 transposase -
XNC1_RS02465 (XNC1_0567) 487847..488812 + 966 WP_010848971.1 PDR/VanB family oxidoreductase -
XNC1_RS20960 (XNC1_0568) 488845..489117 + 273 WP_013183342.1 hypothetical protein -
XNC1_RS02470 (XNC1_0569) 489240..489539 - 300 WP_010848973.1 XRE family transcriptional regulator Antitoxin
XNC1_RS22085 489541..489735 - 195 WP_081480213.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XNC1_RS02475 (XNC1_0570) 489759..490547 - 789 WP_010848974.1 amino acid ABC transporter substrate-binding protein -
XNC1_RS02480 (XNC1_0571) 490601..491365 - 765 WP_010848975.1 amino acid ABC transporter ATP-binding protein -
XNC1_RS02485 (XNC1_0572) 491343..492059 - 717 WP_010848976.1 amino acid ABC transporter permease -
XNC1_RS02490 (XNC1_0574) 492343..493116 - 774 WP_013183344.1 amino acid ABC transporter substrate-binding protein -
XNC1_RS02495 (XNC1_0575) 493320..494028 - 709 Protein_480 transposase -
XNC1_RS20970 (XNC1_0577) 494037..494378 + 342 WP_013183347.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 486526..487668 1142


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-55)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-80)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7507.59 Da        Isoelectric Point: 8.5012

>T24795 WP_081480213.1 NC_014228:c489735-489541 [Xenorhabdus nematophila ATCC 19061]
IDYISIDCSLYTRTIRAFFAFDPERQAVVFCAGNKAGKNQKSFYRDMIKVADEQFRIHLNNLEK

Download         Length: 195 bp

>T24795 NC_014228:c489735-489541 [Xenorhabdus nematophila ATCC 19061]
ATAGACTACATATCTATAGATTGTAGTCTATATACTCGAACAATCCGGGCATTTTTTGCATTTGATCCAGAACGTCAGGC
TGTTGTTTTTTGCGCAGGAAATAAAGCAGGGAAAAACCAAAAGTCATTCTATCGGGATATGATTAAGGTTGCTGACGAAC
AATTCAGAATCCATCTAAACAATTTGGAGAAATGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10868.74 Da        Isoelectric Point: 8.4812

>AT24795 WP_010848973.1 NC_014228:c489539-489240 [Xenorhabdus nematophila ATCC 19061]
MATLKELMAKRSPESQAKIEEKAAEMLLETQLYQIREALALSQTQVAKNLGIAQSSVAAIEQRGNELKISTLKKYIEAMG
GEMTLGVKLPDGKLMNFSI

Download         Length: 300 bp

>AT24795 NC_014228:c489539-489240 [Xenorhabdus nematophila ATCC 19061]
ATGGCTACTTTAAAAGAACTGATGGCAAAACGTAGCCCAGAAAGTCAAGCCAAAATAGAAGAAAAAGCAGCCGAAATGTT
GCTTGAAACGCAACTATACCAAATTCGTGAAGCATTAGCCCTTTCACAAACTCAGGTAGCAAAAAACCTGGGTATAGCCC
AATCATCAGTTGCAGCTATTGAACAACGAGGAAATGAATTGAAAATTTCCACACTGAAAAAATACATTGAAGCGATGGGC
GGCGAAATGACTTTGGGAGTCAAATTACCTGATGGAAAATTAATGAATTTCTCCATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References