Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | VII | Classification (family/domain) | TglT-TakA/AbiEii-AbiEi |
Location | 1169193..1170694 | Replicon | chromosome |
Accession | NZ_CP096848 | ||
Organism | Mycobacterium tuberculosis variant bovis strain Mb0486 |
Toxin (Protein)
Gene name | tglT | Uniprot ID | L7N4P5 |
Locus tag | M1778_RS05600 | Protein ID | WP_003898703.1 |
Coordinates | 1169813..1170694 (+) | Length | 294 a.a. |
Antitoxin (Protein)
Gene name | takA | Uniprot ID | L7N5C7 |
Locus tag | M1778_RS05595 | Protein ID | WP_003405517.1 |
Coordinates | 1169193..1169816 (+) | Length | 208 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M1778_RS05575 (M1778_05575) | 1164688..1165515 | - | 828 | WP_003405370.1 | PE domain-containing protein | - |
M1778_RS05580 (M1778_05580) | 1166303..1166542 | - | 240 | WP_003405375.1 | hypothetical protein | - |
M1778_RS05585 (M1778_05585) | 1166711..1167638 | - | 928 | Protein_1100 | IS5-like element ISMt1 family transposase | - |
M1778_RS05590 (M1778_05590) | 1167921..1168946 | - | 1026 | WP_010950486.1 | serine protease | - |
M1778_RS05595 (M1778_05595) | 1169193..1169816 | + | 624 | WP_003405517.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
M1778_RS05600 (M1778_05600) | 1169813..1170694 | + | 882 | WP_003898703.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
M1778_RS05605 (M1778_05605) | 1171564..1172811 | + | 1248 | WP_003904572.1 | IS256-like element IS1081 family transposase | - |
M1778_RS05610 (M1778_05610) | 1173179..1174294 | - | 1116 | WP_003405582.1 | hypothetical protein | - |
M1778_RS05615 (M1778_05615) | 1174251..1174454 | - | 204 | WP_003405585.1 | hypothetical protein | - |
M1778_RS05620 (M1778_05620) | 1174527..1174973 | + | 447 | WP_003405595.1 | oxidation-sensing regulator MosR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | IScluster/Tn | - | esxN | 1161057..1172811 | 11754 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 294 a.a. Molecular weight: 31958.65 Da Isoelectric Point: 6.3901
>T244040 WP_003898703.1 NZ_CP096848:1169813-1170694 [Mycobacterium tuberculosis variant bovis]
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR
Download Length: 882 bp
Antitoxin
Download Length: 208 a.a. Molecular weight: 22531.68 Da Isoelectric Point: 10.0518
>AT244040 WP_003405517.1 NZ_CP096848:1169193-1169816 [Mycobacterium tuberculosis variant bovis]
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA
Download Length: 624 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|