Detailed information of TA system TA242762

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3782839..3783090
• Replicon: chromosome
• Accession: NZ_CP096118
• Organism: Salmonella enterica subsp. enterica serovar Indiana strain 22

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: MZK41_RS18730
• Protein ID: WP_131166435.1
• Coordinates: 3782839..3783090 (+)
• Length: 84 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3782855..3783080 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MZK41_RS18710	3779367..3780107	-	741	WP_051129375.1	pili assembly chaperone SafB	-
MZK41_RS18715	3780182..3780679	-	498	WP_051129374.1	Saf-pilin pilus formation protein SafA	-
MZK41_RS18720	3780812..3781306	-	495	WP_051129373.1	hypothetical protein	-
MZK41_RS18725	3782074..3782775	-	702	Protein_3674	integrase core domain-containing protein	-
MZK41_RS18730	3782839..3783090	+	252	WP_131166435.1	SymE family type I addiction module toxin	Toxin
-	3782855..3783080	-	226	-	-	Antitoxin
MZK41_RS18735	3783136..3783600	-	465	WP_127201574.1	hypothetical protein	-
MZK41_RS18740	3783981..3784826	-	846	Protein_3677	RHS repeat-associated core domain-containing protein	-
MZK41_RS18745	3784846..3784983	+	138	WP_023227287.1	hypothetical protein	-
MZK41_RS18750	3785126..3785734	-	609	WP_053505599.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3762971..3807286	44315
	-	flank	IS/Tn	-	-	3782074..3782352	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (10-48)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9451.82 Da
• Isoelectric Point: 8.0365

>T242762 WP_131166435.1 NZ_CP096118:3782839-3783090 [Salmonella enterica subsp. enterica serovar Indiana]
MRDTYKTHMTTYYSRIPSLHLKGDWLAEAGFDTGASVTVKISEGCLTLIVETDEVRDLRRELYQVKKSMKHIKAGVYDVV
NGN

Nucleotide

• Length: 252 bp

>T242762 NZ_OW967263:852978-853385 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGCTGTTGATGGATGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCTGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG

Antitoxin

Nucleotide

• Length: 226 bp

>AT242762 NZ_CP096118:c3783080-3782855 [Salmonella enterica subsp. enterica serovar Indiana]
TTCACCACATCATATACCCCCGCCTTAATGTGCTTCATCGACTTTTTCACCTGATAAAGCTCCCTCCGTAGATCCCTCAC
TTCGTCTGTCTCCACAATCAGAGTCAAACACCCTTCGGAGATCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCAGGCTGGGGATGCGCGAGTAATAGGTGGTCATGTGGGTTT

Structures

Antitoxin