Detailed information of TA system TA024260

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-DnaT
• Location: 16394..16925
• Replicon: plasmid pEP36
• Accession: NC_013263
• Organism: Erwinia pyrifoliae Ep1/96

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: E3DL65
• Locus tag: EPC_RS00125
• Protein ID: WP_011078058.1
• Coordinates: 16638..16925 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: Q7X3U3
• Locus tag: EPC_RS00120
• Protein ID: WP_011078059.1
• Coordinates: 16394..16648 (+)
• Length: 85 a.a.

Genomic Context

Location: 12747..12938 (192 bp)
Type: Others
Protein ID: Protein_10

Location: 13314..14246 (933 bp)
Type: Others
Protein ID: WP_041473952.1

Location: 14243..14440 (198 bp)
Type: Others
Protein ID: WP_012814637.1

Location: 14444..15202 (759 bp)
Type: Others
Protein ID: WP_012814638.1

Location: 15218..16183 (966 bp)
Type: Others
Protein ID: WP_011078060.1

Location: 16394..16648 (255 bp)
Type: Antitoxin
Protein ID: WP_011078059.1

Location: 16638..16925 (288 bp)
Type: Toxin
Protein ID: WP_011078058.1

Location: 17085..17369 (285 bp)
Type: Others
Protein ID: WP_011078079.1

Location: 17633..17947 (315 bp)
Type: Others
Protein ID: WP_041473956.1

Location: 17948..18361 (414 bp)
Type: Others
Protein ID: WP_011113999.1

Location: 18869..20425 (1557 bp)
Type: Others
Protein ID: WP_041473953.1

Location: 12013..12597 (585 bp)
Type: Others
Protein ID: WP_012814636.1

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Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EPC_RS00095	12013..12597	-	585	WP_012814636.1	recombinase family protein	-
EPC_RS18745	12747..12938	+	192	Protein_10	Txe/YoeB family addiction module toxin	-
EPC_RS00100	13314..14246	+	933	WP_041473952.1	FAD-dependent oxidoreductase	-
EPC_RS00105	14243..14440	+	198	WP_012814637.1	sulfur carrier protein ThiS	-
EPC_RS00110	14444..15202	+	759	WP_012814638.1	thiazole synthase	-
EPC_RS00115	15218..16183	+	966	WP_011078060.1	ThiF family adenylyltransferase	-
EPC_RS00120	16394..16648	+	255	WP_011078059.1	plasmid stabilization protein	Antitoxin
EPC_RS00125	16638..16925	+	288	WP_011078058.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EPC_RS00130	17085..17369	+	285	WP_011078079.1	VF530 family protein	-
EPC_RS00135	17633..17947	+	315	WP_041473956.1	type II toxin-antitoxin system HigB family toxin	-
EPC_RS00140	17948..18361	+	414	WP_011113999.1	helix-turn-helix domain-containing protein	-
EPC_RS00145	18869..20425	+	1557	WP_041473953.1	MCP four helix bundle domain-containing protein	-

Associated MGEs

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MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_004445 Erwinia pyrifoliae Ep1/96 Non-Mobilizable plasmid TA006130 1..35904 0.003	inside	Non-Mobilizable plasmid	-	pla	1..35909	35909
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_004445 Erwinia pyrifoliae Ep1/96 IS/Tn TA006130 17120..17704 0.001	flank	IS/Tn	-	-	12013..12597	584

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11197.09 Da
• Isoelectric Point: 10.6516

>T24260 WP_011078058.1 NC_013263:16638-16925 [Erwinia pyrifoliae Ep1/96]
MTYKLKFVPSAEKEWKRLGHPVREQFKKKLAERLENPRVPSAQLHGRKDQYKIKLKSAGYRLVYLVQEHTITIMVMGIGK
REGNQIYSDTENRLP

Nucleotide

• Length: 288 bp

>T24260 NC_013263:16638-16925 [Erwinia pyrifoliae Ep1/96]
ATGACTTATAAACTCAAGTTTGTCCCTTCCGCAGAGAAGGAATGGAAAAGGCTCGGGCACCCTGTCAGGGAGCAGTTCAA
AAAAAAGCTTGCTGAACGCCTGGAAAACCCCCGAGTGCCTTCAGCACAGCTTCATGGTCGTAAAGATCAGTACAAAATTA
AGCTAAAGTCTGCCGGTTACAGGCTGGTTTATCTGGTCCAGGAGCACACCATTACGATAATGGTTATGGGCATTGGCAAA
CGTGAAGGTAATCAGATTTACTCTGATACAGAGAACCGGCTTCCCTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9210.56 Da
• Isoelectric Point: 3.8705

>AT24260 WP_011078059.1 NC_013263:16394-16648 [Erwinia pyrifoliae Ep1/96]
MAFNILTNTAASITDLKRDPMGTVRAAEGETIAILNRNEPAFYCVPPAMYAYLMELAEDAELGCIVDDRMSELPVAKEIS
LDDL

Nucleotide

• Length: 255 bp

>AT24260 NC_013263:16394-16648 [Erwinia pyrifoliae Ep1/96]
ATGGCATTCAACATACTCACTAATACCGCAGCAAGCATCACGGATTTGAAGCGCGACCCAATGGGCACAGTCCGTGCTGC
CGAAGGGGAAACTATCGCAATTTTAAACCGTAACGAGCCGGCATTTTATTGCGTACCACCCGCTATGTACGCTTATCTGA
TGGAGCTGGCAGAGGATGCTGAGCTTGGATGTATCGTTGACGATCGCATGTCAGAGTTACCGGTTGCGAAAGAGATATCA
TTGGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
No matching records found

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Antitoxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
No matching records found

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Structures

Toxin

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• AlphaFold DB: E3DL65

Antitoxin

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• AlphaFold DB: Q7X3U3