24260

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 16394..16925 Replicon plasmid pEP36
Accession NC_013263
Organism Erwinia pyrifoliae Ep1/96

Toxin (Protein)


Gene name stbE Uniprot ID E3DL65
Locus tag EPC_RS00125 Protein ID WP_011078058.1
Coordinates 16638..16925 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID Q7X3U3
Locus tag EPC_RS00120 Protein ID WP_011078059.1
Coordinates 16394..16648 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EPC_RS00095 12013..12597 - 585 WP_012814636.1 recombinase family protein -
EPC_RS18745 12747..12938 + 192 Protein_10 Txe/YoeB family addiction module toxin -
EPC_RS00100 13314..14246 + 933 WP_041473952.1 FAD-dependent oxidoreductase -
EPC_RS00105 14243..14440 + 198 WP_012814637.1 sulfur carrier protein ThiS -
EPC_RS00110 14444..15202 + 759 WP_012814638.1 thiazole synthase -
EPC_RS00115 15218..16183 + 966 WP_011078060.1 ThiF family adenylyltransferase -
EPC_RS00120 16394..16648 + 255 WP_011078059.1 plasmid stabilization protein Antitoxin
EPC_RS00125 16638..16925 + 288 WP_011078058.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EPC_RS00130 17085..17369 + 285 WP_011078079.1 VF530 family protein -
EPC_RS00135 17633..17947 + 315 WP_041473956.1 type II toxin-antitoxin system HigB family toxin -
EPC_RS00140 17948..18361 + 414 WP_011113999.1 helix-turn-helix domain-containing protein -
EPC_RS00145 18869..20425 + 1557 WP_041473953.1 MCP four helix bundle domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid - pla 1..35909 35909
flank IS/Tn - - 12013..12597 584


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11197.09 Da        Isoelectric Point: 10.6516

>T24260 WP_011078058.1 NC_013263:16638-16925 [Erwinia pyrifoliae Ep1/96]
MTYKLKFVPSAEKEWKRLGHPVREQFKKKLAERLENPRVPSAQLHGRKDQYKIKLKSAGYRLVYLVQEHTITIMVMGIGK
REGNQIYSDTENRLP

Download         Length: 288 bp

>T24260 NC_013263:16638-16925 [Erwinia pyrifoliae Ep1/96]
ATGACTTATAAACTCAAGTTTGTCCCTTCCGCAGAGAAGGAATGGAAAAGGCTCGGGCACCCTGTCAGGGAGCAGTTCAA
AAAAAAGCTTGCTGAACGCCTGGAAAACCCCCGAGTGCCTTCAGCACAGCTTCATGGTCGTAAAGATCAGTACAAAATTA
AGCTAAAGTCTGCCGGTTACAGGCTGGTTTATCTGGTCCAGGAGCACACCATTACGATAATGGTTATGGGCATTGGCAAA
CGTGAAGGTAATCAGATTTACTCTGATACAGAGAACCGGCTTCCCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9210.56 Da        Isoelectric Point: 3.8705

>AT24260 WP_011078059.1 NC_013263:16394-16648 [Erwinia pyrifoliae Ep1/96]
MAFNILTNTAASITDLKRDPMGTVRAAEGETIAILNRNEPAFYCVPPAMYAYLMELAEDAELGCIVDDRMSELPVAKEIS
LDDL

Download         Length: 255 bp

>AT24260 NC_013263:16394-16648 [Erwinia pyrifoliae Ep1/96]
ATGGCATTCAACATACTCACTAATACCGCAGCAAGCATCACGGATTTGAAGCGCGACCCAATGGGCACAGTCCGTGCTGC
CGAAGGGGAAACTATCGCAATTTTAAACCGTAACGAGCCGGCATTTTATTGCGTACCACCCGCTATGTACGCTTATCTGA
TGGAGCTGGCAGAGGATGCTGAGCTTGGATGTATCGTTGACGATCGCATGTCAGAGTTACCGGTTGCGAAAGAGATATCA
TTGGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3DL65

Antitoxin

Source ID Structure
AlphaFold DB Q7X3U3

References