Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1410726..1411097 Replicon chromosome
Accession NC_012967
Organism Escherichia coli B str. REL606

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag ECB_RS07055 Protein ID WP_001317028.1
Coordinates 1410903..1411097 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1410726..1410904 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECB_RS07030 1406681..1408054 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
ECB_RS07035 1408183..1409118 - 936 WP_001157407.1 tRNA 2-thiocytidine(32) synthetase TtcA -
ECB_RS23520 1409170..1410405 - 1236 WP_000040858.1 site-specific integrase -
ECB_RS07045 1410407..1410622 - 216 WP_000079604.1 excisionase XisR -
ECB_RS07050 1410701..1410910 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1410726..1410904 + 179 NuclAT_0 - Antitoxin
- 1410726..1410904 + 179 NuclAT_0 - Antitoxin
- 1410726..1410904 + 179 NuclAT_0 - Antitoxin
- 1410726..1410904 + 179 NuclAT_0 - Antitoxin
ECB_RS07055 1410903..1411097 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
ECB_RS07060 1411154..1411963 - 810 WP_000166319.1 recombination protein RecT -
ECB_RS07065 1411956..1414556 - 2601 WP_000105139.1 exodeoxyribonuclease VIII -
ECB_RS07070 1414658..1414933 - 276 WP_000632297.1 protein RacC -
ECB_RS07075 1415008..1415178 - 171 WP_001352098.1 conserved protein, Rac prophage -
ECB_RS07080 1415178..1415399 - 222 WP_000560223.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1409170..1425280 16110


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T24116 WP_001317028.1 NC_012967:c1411097-1410903 [Escherichia coli B str. REL606]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T24116 NC_012967:c1411097-1410903 [Escherichia coli B str. REL606]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 179 bp

>AT24116 NC_012967:1410726-1410904 [Escherichia coli B str. REL606]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References