Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1949808..1949990 Replicon chromosome
Accession NZ_CP094855
Organism Staphylococcus aureus strain NY2491

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag MTX64_RS09545 Protein ID WP_001801861.1
Coordinates 1949808..1949903 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1949931..1949990 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX64_RS09505 1945468..1946094 + 627 WP_000669046.1 hypothetical protein -
MTX64_RS09510 1946135..1946479 + 345 WP_000627551.1 DUF3969 family protein -
MTX64_RS09515 1946577..1947128 + 552 WP_000414205.1 hypothetical protein -
MTX64_RS09520 1947346..1947987 - 642 WP_000494956.1 ImmA/IrrE family metallo-endopeptidase -
MTX64_RS09525 1948101..1948286 - 186 WP_000809857.1 hypothetical protein -
MTX64_RS09530 1948288..1948464 - 177 WP_000375476.1 hypothetical protein -
MTX64_RS09535 1948475..1948858 - 384 WP_000070811.1 hypothetical protein -
MTX64_RS09540 1949462..1949605 - 144 WP_001549059.1 transposase -
MTX64_RS09545 1949808..1949903 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1949931..1949990 - 60 - - Antitoxin
MTX64_RS09550 1950026..1950127 + 102 WP_001791893.1 hypothetical protein -
MTX64_RS09555 1950105..1950281 - 177 Protein_1886 transposase -
MTX64_RS09560 1950475..1950852 - 378 WP_001037045.1 DUF1433 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA 1942908..1980084 37176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T240675 WP_001801861.1 NZ_CP094855:1949808-1949903 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T240675 NZ_LT615228:c1796997-1796710 [Polynucleobacter necessarius]
ATGAGAGTCATTACTAATCGTCGCTTATTAGAGTTTGCAGCCTCTCACAAAGATGCCTCTGCGCCACTCCAGGCCTGGAG
AAAATTAATGAAGTTTGGGTCCTACGCAAATTTTGCCGATATTCGACAAGTTTTTAGAGCAGTCGACAAAGTTGGTGACT
TGTATGTTTTTAATATTTGTGGAAATAAATATCGTCTGATTACATTCTTGCAGTTTGAAAGACAGCTTTGTTACATCAAA
GCCGTGTTAACTCATAAGCAATACGATAAAGATGGGTGGAAAAAATGA

Antitoxin


Download         Length: 60 bp

>AT240675 NZ_CP094855:c1949990-1949931 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References