Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1340691..1340871 Replicon chromosome
Accession NZ_CP094663
Organism Staphylococcus aureus strain 494

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag MT995_RS06450 Protein ID WP_001801861.1
Coordinates 1340691..1340786 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1340814..1340871 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT995_RS06420 1335854..1336504 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
MT995_RS06425 1336585..1337580 + 996 WP_000070642.1 DUF4352 domain-containing protein -
MT995_RS06430 1337655..1338281 + 627 WP_000669024.1 hypothetical protein -
MT995_RS06435 1338322..1338663 + 342 WP_000627540.1 DUF3969 family protein -
MT995_RS06440 1338764..1339336 + 573 WP_000414216.1 hypothetical protein -
MT995_RS06445 1339534..1340546 - 1013 Protein_1276 IS3 family transposase -
MT995_RS06450 1340691..1340786 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1340814..1340871 - 58 - - Antitoxin
MT995_RS06455 1340909..1341010 + 102 WP_001792025.1 hypothetical protein -
MT995_RS06460 1340988..1341149 - 162 Protein_1279 transposase -
MT995_RS06465 1341134..1341544 - 411 WP_001808705.1 IS21 family transposase -
MT995_RS06470 1342085..1343314 - 1230 WP_000072627.1 restriction endonuclease subunit S -
MT995_RS06475 1343307..1344863 - 1557 WP_000028669.1 type I restriction-modification system subunit M -
MT995_RS06480 1345027..1345161 - 135 WP_001791797.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA / selk 1335096..1366823 31727


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T239978 WP_001801861.1 NZ_CP094663:1340691-1340786 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T239978 NZ_LS483424:2654233-2654499 [Bordetella parapertussis]
ATGGATATCACCTACGACCCCGCCAAGAACGACAAGAACATTGCCGATCGCGGCCTGTCGTTCGAGTTGGTGTGTGGCTT
CGAGTGGGCCAGCGCGCTGGTGGTTGAGGATACCCGCCAGGTCTACGCCGAAACGCGCTATCAGGCGCTGGGCAAAATCG
ATGGCCGGCTCCATATGGTGGTATTCACGGTGCGCGGCGAGTCGCTGCGCATCATCAGCCTGCGTAAGGCAAATGCTCGT
GAGGTAGCTCGTTATGAAAAAGCCTGA

Antitoxin


Download         Length: 58 bp

>AT239978 NZ_CP094663:c1340871-1340814 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References