Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1908243..1908423 Replicon chromosome
Accession NZ_CP093935
Organism Staphylococcus aureus strain WA121-2021_16354

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag MQP46_RS09315 Protein ID WP_001801861.1
Coordinates 1908243..1908338 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1908366..1908423 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQP46_RS09285 1903406..1904056 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
MQP46_RS09290 1904137..1905132 + 996 WP_000070642.1 DUF4352 domain-containing protein -
MQP46_RS09295 1905207..1905833 + 627 WP_000669024.1 hypothetical protein -
MQP46_RS09300 1905874..1906215 + 342 WP_000627540.1 DUF3969 family protein -
MQP46_RS09305 1906316..1906888 + 573 WP_000414216.1 hypothetical protein -
MQP46_RS09310 1907086..1908098 - 1013 Protein_1832 IS3 family transposase -
MQP46_RS09315 1908243..1908338 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1908366..1908423 - 58 - - Antitoxin
MQP46_RS09320 1908461..1908562 + 102 WP_001792025.1 hypothetical protein -
MQP46_RS09325 1908540..1908701 - 162 Protein_1835 transposase -
MQP46_RS09330 1908686..1909096 - 411 WP_001808705.1 IS21 family transposase -
MQP46_RS09335 1909638..1910867 - 1230 WP_000072627.1 restriction endonuclease subunit S -
MQP46_RS09340 1910860..1912416 - 1557 WP_000028669.1 type I restriction-modification system subunit M -
MQP46_RS09345 1912580..1912714 - 135 WP_001791797.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA / selk 1902648..1935256 32608


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-45)


Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T239108 WP_001801861.1 NZ_CP093935:1908243-1908338 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T239108 NZ_LR890604:c86862-86713 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 58 bp

>AT239108 NZ_CP093935:c1908423-1908366 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References