Detailed information of TA system TA238605

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3766678..3767080
• Replicon: chromosome
• Accession: NZ_CP093445
• Organism: Salmonella enterica subsp. enterica serovar Abeokuta strain OG19FER4

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V9S8T1
• Locus tag: MOV10_RS18410
• Protein ID: WP_000994223.1
• Coordinates: 3766835..3767080 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3766678..3767044 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOV10_RS18375	3761927..3762427	-	501	WP_242105337.1	pilus assembly protein	-
MOV10_RS18380	3763188..3763892	-	705	Protein_3602	integrase core domain-containing protein	-
MOV10_RS18385	3763945..3764259	+	315	WP_079827314.1	SymE family type I addiction module toxin	-
MOV10_RS18390	3764326..3764604	-	279	WP_197391361.1	hypothetical protein	-
MOV10_RS18395	3764922..3765389	-	468	WP_000828182.1	sugar tyrosine-protein kinase	-
MOV10_RS18400	3765482..3765706	-	225	WP_023138331.1	hypothetical protein	-
MOV10_RS18405	3766207..3766500	-	294	WP_129369132.1	hypothetical protein	-
-	3766678..3767044	-	367	-	-	Antitoxin
MOV10_RS18410	3766835..3767080	+	246	WP_000994223.1	hypothetical protein	Toxin
MOV10_RS18415	3767147..3767689	-	543	WP_079984650.1	hypothetical protein	-
MOV10_RS18420	3767689..3771795	-	4107	WP_242105338.1	RHS repeat-associated core domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3754029..3789220	35191
	-	flank	IS/Tn	-	-	3763188..3763469	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8789.96 Da
• Isoelectric Point: 4.1428

>T238605 WP_000994223.1 NZ_CP093445:3766835-3767080 [Salmonella enterica subsp. enterica serovar Abeokuta]
MNASGVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

>T238605 NZ_LR890410:c3444403-3444146 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Nucleotide

• Length: 367 bp

>AT238605 NZ_CP093445:c3767044-3766678 [Salmonella enterica subsp. enterica serovar Abeokuta]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCATGGCACTGTGCCCCCCTCTCCCCG
GCCAGCACTGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V9S8T1

Antitoxin