Detailed information of TA system TA238573

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3713737..3714151
• Replicon: chromosome
• Accession: NZ_CP093411
• Organism: Salmonella enterica subsp. enterica serovar Agona strain R18.0246

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: B5F8Y1
• Locus tag: MOP53_RS18220
• Protein ID: WP_000994221.1
• Coordinates: 3713894..3714151 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3713737..3714115 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOP53_RS18190	3709060..3709557	-	498	WP_000835844.1	Saf-pilin pilus formation protein SafA	-
MOP53_RS18195	3710318..3711022	-	705	Protein_3569	integrase core domain-containing protein	-
MOP53_RS18200	3711106..3711255	+	150	WP_151273333.1	type I toxin-antitoxin system SymE family toxin	-
MOP53_RS18205	3711387..3711665	-	279	WP_077905764.1	hypothetical protein	-
MOP53_RS18210	3711983..3712450	-	468	WP_000828177.1	sugar tyrosine-protein kinase	-
MOP53_RS18215	3713267..3713560	-	294	WP_138017652.1	hypothetical protein	-
-	3713737..3714115	-	379	-	-	Antitoxin
MOP53_RS18220	3713894..3714151	+	258	WP_000994221.1	SymE family type I addiction module toxin	Toxin
MOP53_RS18225	3714218..3714649	-	432	WP_023135248.1	hypothetical protein	-
MOP53_RS18230	3714721..3715137	-	417	WP_001748027.1	DUF2195 family protein	-
MOP53_RS18235	3715134..3715502	-	369	Protein_3577	hypothetical protein	-
MOP53_RS18240	3715501..3715566	+	66	Protein_3578	hypothetical protein	-
MOP53_RS18245	3715816..3716001	-	186	Protein_3579	transposase	-
MOP53_RS18250	3716101..3716772	-	672	WP_000058649.1	ankyrin repeat domain-containing protein	-
MOP53_RS18255	3716788..3717273	-	486	WP_000103455.1	hypothetical protein	-
MOP53_RS18260	3717615..3717851	+	237	WP_130549554.1	hypothetical protein	-
MOP53_RS18265	3717933..3718109	+	177	Protein_3583	phage integrase N-terminal domain-containing protein	-
MOP53_RS18270	3718577..3718939	-	363	WP_001748026.1	Arm DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3701162..3718939	17777

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9356.66 Da
• Isoelectric Point: 5.6373

>T238573 WP_000994221.1 NZ_CP093411:3713894-3714151 [Salmonella enterica subsp. enterica serovar Agona]
MNASGVSVRHINSETCITTCYSQIPSQHLKGDWQEEAGFETGRSVTVKISQGCIVLMADGNEVQKLCEQLYQAERVVKGL
KDVLV

Nucleotide

• Length: 258 bp

>T238573 NZ_LR890405:c843483-843106 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Nucleotide

• Length: 379 bp

>AT238573 NZ_CP093411:c3714115-3713737 [Salmonella enterica subsp. enterica serovar Agona]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCCTGTGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAG
TAACAGGTGGTTATACAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAA
TTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCC
CCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3L1ZDZ2

Antitoxin