Detailed information of TA system TA238550

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3741171..3741585
• Replicon: chromosome
• Accession: NZ_CP093407
• Organism: Salmonella enterica subsp. enterica serovar Agona strain R19.0144

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: B5F8Y1
• Locus tag: MOP55_RS18415
• Protein ID: WP_000994221.1
• Coordinates: 3741328..3741585 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3741171..3741549 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOP55_RS18385	3736494..3736991	-	498	WP_000835844.1	Saf-pilin pilus formation protein SafA	-
MOP55_RS18390	3737752..3738456	-	705	Protein_3608	integrase core domain-containing protein	-
MOP55_RS18395	3738540..3738689	+	150	WP_151273333.1	type I toxin-antitoxin system SymE family toxin	-
MOP55_RS18400	3738821..3739099	-	279	WP_077905764.1	hypothetical protein	-
MOP55_RS18405	3739417..3739884	-	468	WP_000828177.1	sugar tyrosine-protein kinase	-
MOP55_RS18410	3740701..3741120	-	420	WP_130549555.1	hypothetical protein	-
-	3741171..3741549	-	379	-	-	Antitoxin
MOP55_RS18415	3741328..3741585	+	258	WP_000994221.1	SymE family type I addiction module toxin	Toxin
MOP55_RS18420	3741652..3742083	-	432	WP_023135248.1	hypothetical protein	-
MOP55_RS18425	3742155..3742571	-	417	WP_001748027.1	DUF2195 family protein	-
MOP55_RS18430	3742568..3742936	-	369	Protein_3616	hypothetical protein	-
MOP55_RS18435	3742935..3743000	+	66	Protein_3617	hypothetical protein	-
MOP55_RS18440	3743250..3743435	-	186	Protein_3618	transposase	-
MOP55_RS18445	3743535..3744206	-	672	WP_000058649.1	ankyrin repeat domain-containing protein	-
MOP55_RS18450	3744222..3744707	-	486	WP_000103455.1	hypothetical protein	-
MOP55_RS18455	3745049..3745285	+	237	WP_130549554.1	hypothetical protein	-
MOP55_RS18460	3745367..3745543	+	177	Protein_3622	phage integrase N-terminal domain-containing protein	-
MOP55_RS18465	3746011..3746373	-	363	WP_001748026.1	Arm DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3727843..3750956	23113

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9356.66 Da
• Isoelectric Point: 5.6373

>T238550 WP_000994221.1 NZ_CP093407:3741328-3741585 [Salmonella enterica subsp. enterica serovar Agona]
MNASGVSVRHINSETCITTCYSQIPSQHLKGDWQEEAGFETGRSVTVKISQGCIVLMADGNEVQKLCEQLYQAERVVKGL
KDVLV

Nucleotide

• Length: 258 bp

>T238550 NZ_LR890391:3970421-3970639 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Nucleotide

• Length: 379 bp

>AT238550 NZ_CP093407:c3741549-3741171 [Salmonella enterica subsp. enterica serovar Agona]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCCTGTGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAG
TAACAGGTGGTTATACAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAA
TTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCC
CCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3L1ZDZ2

Antitoxin